ID   E7EPT6_HUMAN            Unreviewed;       165 AA.
AC   E7EPT6;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-JAN-2019, entry version 53.
DE   SubName: Full=Protransforming growth factor alpha {ECO:0000313|Ensembl:ENSP00000414127};
GN   Name=TGFA {ECO:0000313|Ensembl:ENSP00000414127};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000414127, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000414127, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000414127}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; AC005234; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC017084; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001295088.1; NM_001308159.1.
DR   UniGene; Hs.170009; -.
DR   UniGene; Hs.628298; -.
DR   ProteinModelPortal; E7EPT6; -.
DR   jPOST; E7EPT6; -.
DR   Ensembl; ENST00000450929; ENSP00000414127; ENSG00000163235.
DR   GeneID; 7039; -.
DR   UCSC; uc010fdr.4; human.
DR   CTD; 7039; -.
DR   EuPathDB; HostDB:ENSG00000163235.15; -.
DR   HGNC; HGNC:11765; TGFA.
DR   OpenTargets; ENSG00000163235; -.
DR   GeneTree; ENSGT00940000160058; -.
DR   OrthoDB; 1401257at2759; -.
DR   ChiTaRS; TGFA; human.
DR   GenomeRNAi; 7039; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000163235; Expressed in 192 organ(s), highest expression level in pigmented layer of retina.
DR   ExpressionAtlas; E7EPT6; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR015497; EGF_rcpt_ligand.
DR   PANTHER; PTHR10740; PTHR10740; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:E7EPT6,
KW   ECO:0000213|PeptideAtlas:E7EPT6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    165       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003217483.
FT   TRANSMEM    105    127       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       48     88       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DISULFID     78     87       {ECO:0000256|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   165 AA;  17719 MW;  3494D4796413D984 CRC64;
     MFKIGRGALD LFSELLSFGG IVLAACQALE NSTSPLSDPP VAAAVVSHFN DCPDSHTQFC
     FHGTCRFLVQ EDKPACVCHS GYVGARCEHA DLLAVVAASQ KKQAITALVV VSIVALAVLI
     ITCVLIHCCQ VRKHCEWCRA LICRHEKPSA LLKGRTACCH SETVV
//