ID   E7EPA6_HUMAN            Unreviewed;       850 AA.
AC   E7EPA6;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-JAN-2019, entry version 59.
DE   SubName: Full=Laminin subunit beta-1 {ECO:0000313|Ensembl:ENSP00000377190};
GN   Name=LAMB1 {ECO:0000313|Ensembl:ENSP00000377190};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000377190, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000377190, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000377190}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR   EMBL; AC005046; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC078853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E7EPA6; -.
DR   iPTMnet; E7EPA6; -.
DR   jPOST; E7EPA6; -.
DR   MaxQB; E7EPA6; -.
DR   PeptideAtlas; E7EPA6; -.
DR   PRIDE; E7EPA6; -.
DR   Ensembl; ENST00000393560; ENSP00000377190; ENSG00000091136.
DR   UCSC; uc003vex.4; human.
DR   EuPathDB; HostDB:ENSG00000091136.13; -.
DR   HGNC; HGNC:6486; LAMB1.
DR   OpenTargets; ENSG00000091136; -.
DR   eggNOG; KOG0994; Eukaryota.
DR   eggNOG; ENOG410XPEG; LUCA.
DR   GeneTree; ENSGT00940000156003; -.
DR   ChiTaRS; LAMB1; human.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000091136; Expressed in 224 organ(s), highest expression level in lower esophagus.
DR   ExpressionAtlas; E7EPA6; baseline and differential.
DR   Gene3D; 2.60.120.1490; -; 1.
DR   InterPro; IPR002049; Laminin_EGF.
DR   InterPro; IPR013015; Laminin_IV_B.
DR   InterPro; IPR008211; Laminin_N.
DR   InterPro; IPR038684; Laminin_N_sf.
DR   Pfam; PF00053; Laminin_EGF; 6.
DR   Pfam; PF00055; Laminin_N; 1.
DR   SMART; SM00180; EGF_Lam; 6.
DR   SMART; SM00136; LamNT; 1.
DR   PROSITE; PS01248; EGF_LAM_1; 2.
DR   PROSITE; PS50027; EGF_LAM_2; 6.
DR   PROSITE; PS51116; LAMININ_IVB; 1.
DR   PROSITE; PS51117; LAMININ_NTER; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00460,
KW   ECO:0000256|SAAS:SAAS00966286};
KW   Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460};
KW   Proteomics identification {ECO:0000213|EPD:E7EPA6,
KW   ECO:0000213|MaxQB:E7EPA6, ECO:0000213|PeptideAtlas:E7EPA6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    850       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003217315.
FT   DOMAIN       31    270       Laminin N-terminal.
FT                                {ECO:0000259|PROSITE:PS51117}.
FT   DOMAIN      271    334       Laminin EGF-like.
FT                                {ECO:0000259|PROSITE:PS50027}.
FT   DOMAIN      335    397       Laminin EGF-like.
FT                                {ECO:0000259|PROSITE:PS50027}.
FT   DOMAIN      398    457       Laminin EGF-like.
FT                                {ECO:0000259|PROSITE:PS50027}.
FT   DOMAIN      458    509       Laminin EGF-like.
FT                                {ECO:0000259|PROSITE:PS50027}.
FT   DOMAIN      510    555       Laminin EGF-like.
FT                                {ECO:0000259|PROSITE:PS50027}.
FT   DOMAIN      549    767       Laminin IV type B.
FT                                {ECO:0000259|PROSITE:PS51116}.
FT   DOMAIN      773    820       Laminin EGF-like.
FT                                {ECO:0000259|PROSITE:PS50027}.
FT   DISULFID    300    309       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    365    374       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    428    437       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    481    490       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    493    507       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    510    522       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    512    529       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    531    540       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    773    785       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    775    792       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    794    803       {ECO:0000256|PROSITE-ProRule:PRU00460}.
SQ   SEQUENCE   850 AA;  95142 MW;  F4A1A3AE9A8D6B82 CRC64;
     MGLLQLLAFS FLALCRARVR AQEPEFSYGC AEGSCYPATG DLLIGRAQKL SVTSTCGLHK
     PEPYCIVSHL QEDKKCFICN SQDPYHETLN PDSHLIENVV TTFAPNRLKI WWQSENGVEN
     VTIQLDLEAE FHFTHLIMTF KTFRPAAMLI ERSSDFGKTW GVYRYFAYDC EASFPGISTG
     PMKKVDDIIC DSRYSDIEPS TEGEVIFRAL DPAFKIEDPY SPRIQNLLKI TNLRIKFVKL
     HTLGDNLLDS RMEIREKYYY AVYDMVVRGN CFCYGHASEC APVDGFNEEV EGMVHGHCMC
     RHNTKGLNCE LCMDFYHDLP WRPAEGRNSN ACKKCNCNEH SISCHFDMAV YLATGNVSGG
     VCDDCQHNTM GRNCEQCKPF YYQHPERDIR DPNFCERCTC DPAGSQNEGI CDSYTDFSTG
     LIAGQCRCKL NVEGEHCDVC KEGFYDLSSE DPFGCKSCAC NPLGTIPGGN PCDSETGHCY
     CKRLVTGQHC DQCLPEHWGL SNDLDGCRPC DCDLGGALNN SCFAESGQCS CRPHMIGRQC
     NEVEPGYYFA TLDHYLYEAE EANLGPGVSI VERQYIQDRI PSWTGAGFVR VPEGAYLEFF
     IDNIPYSMEY DILIRYEPQL PDHWEKAVIT VQRPGRIPTS SRCGNTIPDD DNQVVSLSPG
     SRYVVLPRPV CFEKGTNYTV RLELPQYTSS DSDVESPYTL IDSLVLMPYC KSLDIFTVGG
     SGDGVVTNSA WETFQRYRCL ENSRSVVKTP MTDVCRNIIF SISALLHQTG LACECDPQGS
     LSSVCDPNGG QCQCRPNVVG RTCNRCAPGT FGFGPSGCKR RFLKSIVMHS FRLTQPLWQG
     SIAAEPMLPS
//