ID   E7EP60_HUMAN            Unreviewed;       614 AA.
AC   E7EP60;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   13-FEB-2019, entry version 61.
DE   SubName: Full=Integrin alpha-4 {ECO:0000313|Ensembl:ENSP00000233573};
DE   Flags: Fragment;
GN   Name=ITGA4 {ECO:0000313|Ensembl:ENSP00000233573};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000233573, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000233573, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000233573}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit.
CC       {ECO:0000256|SAAS:SAAS01130601}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003762};
CC       Single-pass type I membrane protein
CC       {ECO:0000256|RuleBase:RU003762}.
CC   -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC       {ECO:0000256|RuleBase:RU003762, ECO:0000256|SAAS:SAAS00554416}.
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DR   EMBL; AC020595; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E7EP60; -.
DR   jPOST; E7EP60; -.
DR   MaxQB; E7EP60; -.
DR   PeptideAtlas; E7EP60; -.
DR   PRIDE; E7EP60; -.
DR   Ensembl; ENST00000233573; ENSP00000233573; ENSG00000115232.
DR   UCSC; uc061qhz.1; human.
DR   EuPathDB; HostDB:ENSG00000115232.13; -.
DR   HGNC; HGNC:6140; ITGA4.
DR   OpenTargets; ENSG00000115232; -.
DR   eggNOG; ENOG410IPB2; Eukaryota.
DR   eggNOG; ENOG410XTAR; LUCA.
DR   GeneTree; ENSGT00940000158443; -.
DR   ChiTaRS; ITGA4; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000115232; Expressed in 124 organ(s), highest expression level in leukocyte.
DR   ExpressionAtlas; E7EP60; baseline and differential.
DR   GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.130; -; 1.
DR   InterPro; IPR013517; FG-GAP.
DR   InterPro; IPR013519; Int_alpha_beta-p.
DR   InterPro; IPR000413; Integrin_alpha.
DR   InterPro; IPR013649; Integrin_alpha-2.
DR   InterPro; IPR028994; Integrin_alpha_N.
DR   InterPro; IPR032695; Integrin_dom_sf.
DR   Pfam; PF01839; FG-GAP; 2.
DR   Pfam; PF08441; Integrin_alpha2; 1.
DR   PRINTS; PR01185; INTEGRINA.
DR   SMART; SM00191; Int_alpha; 5.
DR   SUPFAM; SSF69179; SSF69179; 1.
DR   PROSITE; PS51470; FG_GAP; 7.
PE   1: Evidence at protein level;
KW   Cell adhesion {ECO:0000256|RuleBase:RU003762,
KW   ECO:0000256|SAAS:SAAS00440260};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Integrin {ECO:0000256|RuleBase:RU003762,
KW   ECO:0000256|SAAS:SAAS00494682};
KW   Membrane {ECO:0000256|SAAS:SAAS00494657};
KW   Proteomics identification {ECO:0000213|EPD:E7EP60,
KW   ECO:0000213|MaxQB:E7EP60, ECO:0000213|PeptideAtlas:E7EP60};
KW   Receptor {ECO:0000256|RuleBase:RU003762,
KW   ECO:0000256|SAAS:SAAS00440269};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00504086};
KW   Signal {ECO:0000256|RuleBase:RU003762};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00494657};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00494657}.
FT   SIGNAL        1     33       {ECO:0000256|RuleBase:RU003762}.
FT   CHAIN        34    614       {ECO:0000256|RuleBase:RU003762}.
FT                                /FTId=PRO_5001424251.
FT   REPEAT       35    100       FG-GAP. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00803}.
FT   REPEAT      110    177       FG-GAP. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00803}.
FT   REPEAT      185    237       FG-GAP. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00803}.
FT   REPEAT      238    291       FG-GAP. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00803}.
FT   REPEAT      292    351       FG-GAP. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00803}.
FT   REPEAT      355    412       FG-GAP. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00803}.
FT   REPEAT      416    478       FG-GAP. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00803}.
FT   DOMAIN      463    611       Integrin_alpha2.
FT                                {ECO:0000259|Pfam:PF08441}.
FT   NON_TER     614    614       {ECO:0000313|Ensembl:ENSP00000233573}.
SQ   SEQUENCE   614 AA;  67508 MW;  B8BF40778C3347B0 CRC64;
     MAWEARREPG PRRAAVRETV MLLLCLGVPT GRPYNVDTES ALLYQGPHNT LFGYSVVLHS
     HGANRWLLVG APTANWLANA SVINPGAIYR CRIGKNPGQT CEQLQLGSPN GEPCGKTCLE
     ERDNQWLGVT LSRQPGENGS IVTCGHRWKN IFYIKNENKL PTGGCYGVPP DLRTELSKRI
     APCYQDYVKK FGENFASCQA GISSFYTKDL IVMGAPGSSY WTGSLFVYNI TTNKYKAFLD
     KQNQVKFGSY LGYSVGAGHF RSQHTTEVVG GAPQHEQIGK AYIFSIDEKE LNILHEMKGK
     KLGSYFGASV CAVDLNADGF SDLLVGAPMQ STIREEGRVF VYINSGSGAV MNAMETNLVG
     SDKYAARFGE SIVNLGDIDN DGFEDVAIGA PQEDDLQGAI YIYNGRADGI SSTFSQRIEG
     LQISKSLSMF GQSISGQIDA DNNGYVDVAV GAFRSDSAVL LRTRPVVIVD ASLSHPESVN
     RTKFDCVENG WPSVCIDLTL CFSYKGKEVP GYIVLFYNMS LDVNRKAESP PRFYFSSNGT
     SDVITGSIQV SSREANCRTH QAFMRKDVRD ILTPIQIEAA YHLGPHVISK RSTEEFPPLQ
     PILQQKKEKD IMKK
//