ID   E7ENX6_HUMAN            Unreviewed;       418 AA.
AC   E7ENX6;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 2.
DT   05-DEC-2018, entry version 62.
DE   SubName: Full=Leucine-rich repeat and fibronectin type-III domain-containing protein 4 {ECO:0000313|Ensembl:ENSP00000377524};
GN   Name=LRFN4 {ECO:0000313|Ensembl:ENSP00000377524};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000377524, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000377524, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000377524}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AP003176; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E7ENX6; -.
DR   MaxQB; E7ENX6; -.
DR   PeptideAtlas; E7ENX6; -.
DR   PRIDE; E7ENX6; -.
DR   Ensembl; ENST00000393952; ENSP00000377524; ENSG00000173621.
DR   UCSC; uc058ebx.1; human.
DR   EuPathDB; HostDB:ENSG00000173621.8; -.
DR   HGNC; HGNC:28456; LRFN4.
DR   OpenTargets; ENSG00000173621; -.
DR   GeneTree; ENSGT00940000162195; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000173621; Expressed in 168 organ(s), highest expression level in cerebellar hemisphere.
DR   ExpressionAtlas; E7ENX6; baseline and differential.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF13855; LRR_8; 2.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00369; LRR_TYP; 6.
DR   SMART; SM00082; LRRCT; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS01010727};
KW   Immunoglobulin domain {ECO:0000256|SAAS:SAAS01010457};
KW   Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:E7ENX6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00597472};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     16       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        17    418       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003218969.
FT   DOMAIN      281    367       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   418 AA;  44395 MW;  E3D6EDD7C569AECE CRC64;
     MAPPLLLLLL ASGAAACPLP CVCQNLSESL STLCAHRGLL FVPPNVDRRT VELRLADNFI
     QALGPPDFRN MTGLVDLTLS RNAITRIGAR AFGDLESLRS LHLDGNRLVE LGTGSLRGPV
     NLQHLILSGN QLGRIAPGAF DDFLESLEDL DLSYNNLRQV PWAGIGAMPA LHTLNLDHNL
     IDALPPGAFA QLGQLSRLDL TSNRLATLAP DPLFSRGRDA EASPAPLVLS FSGNPLHCNC
     ELLWLRRLAR PDDLETCASP PGLAGRYFWA VPEGEFSCEP PLIARHTQRL WVLEGQRATL
     RCRALGDPAP TMHWVGPDDR LVGNSSRARA FPNGTLEIGV TGAGDAGGYT CIATNPAGEA
     TARVELRVLA LPHGGNSRPG AAAWPGSPSL VFILSTSGSP VYLEGQGALS SVLASRPG
//