ID   E7ENX0_HUMAN            Unreviewed;       204 AA.
AC   E7ENX0;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-JAN-2019, entry version 52.
DE   SubName: Full=Prolyl 4-hydroxylase subunit alpha-2 {ECO:0000313|Ensembl:ENSP00000389523};
DE   Flags: Fragment;
GN   Name=P4HA2 {ECO:0000313|Ensembl:ENSP00000389523};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000389523, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000389523, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000389523}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC034220; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC063976; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877101; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E7ENX0; -.
DR   SMR; E7ENX0; -.
DR   jPOST; E7ENX0; -.
DR   MaxQB; E7ENX0; -.
DR   PeptideAtlas; E7ENX0; -.
DR   PRIDE; E7ENX0; -.
DR   Ensembl; ENST00000417528; ENSP00000389523; ENSG00000072682.
DR   UCSC; uc063gto.1; human.
DR   EuPathDB; HostDB:ENSG00000072682.18; -.
DR   HGNC; HGNC:8547; P4HA2.
DR   OpenTargets; ENSG00000072682; -.
DR   eggNOG; KOG1591; Eukaryota.
DR   eggNOG; ENOG410XS5J; LUCA.
DR   GeneTree; ENSGT00940000157695; -.
DR   ChiTaRS; P4HA2; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000072682; Expressed in 211 organ(s), highest expression level in tibia.
DR   ExpressionAtlas; E7ENX0; baseline and differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:HPA.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR   GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:InterPro.
DR   GO; GO:0004656; F:procollagen-proline 4-dioxygenase activity; IEA:InterPro.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR013547; Pro_4_hyd_alph_N.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   Pfam; PF08336; P4Ha_N; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:E7ENX0,
KW   ECO:0000213|MaxQB:E7ENX0, ECO:0000213|PeptideAtlas:E7ENX0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    204       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003217475.
FT   DOMAIN       26    156       P4Ha_N. {ECO:0000259|Pfam:PF08336}.
FT   NON_TER     204    204       {ECO:0000313|Ensembl:ENSP00000389523}.
SQ   SEQUENCE   204 AA;  22864 MW;  2C1A754D6FF6C971 CRC64;
     MKLWVSALLM AWFGVLSCVQ AEFFTSIGHM TDLIYAEKEL VQSLKEYILV EEAKLSKIKS
     WANKMEALTS KSAADAEGYL AHPVNAYKLV KRLNTDWPAL EDLVLQDSAA GFIANLSVQR
     QFFPTDEDEI GAAKALMRLQ DTYRLDPGTI SRGELPGTKY QAMLSVDDCF GMGRSAYNEG
     DYYHTVLWME QVLKQLDAGE EATT
//