ID E7ENL6_HUMAN Unreviewed; 2569 AA. AC E7ENL6; DT 08-MAR-2011, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 2. DT 16-JAN-2019, entry version 61. DE SubName: Full=Collagen alpha-3(VI) chain {ECO:0000313|Ensembl:ENSP00000315609}; GN Name=COL6A3 {ECO:0000313|Ensembl:ENSP00000315609}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000315609, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000315609, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [2] {ECO:0000313|Ensembl:ENSP00000315609} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [3] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC112715; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC112721; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; E7ENL6; -. DR SMR; E7ENL6; -. DR EPD; E7ENL6; -. DR jPOST; E7ENL6; -. DR PeptideAtlas; E7ENL6; -. DR PRIDE; E7ENL6; -. DR Ensembl; ENST00000347401; ENSP00000315609; ENSG00000163359. DR UCSC; uc061tzm.1; human. DR EuPathDB; HostDB:ENSG00000163359.15; -. DR HGNC; HGNC:2213; COL6A3. DR OpenTargets; ENSG00000163359; -. DR GeneTree; ENSGT00940000156462; -. DR ChiTaRS; COL6A3; human. DR Proteomes; UP000005640; Chromosome 2. DR Bgee; ENSG00000163359; Expressed in 215 organ(s), highest expression level in uterine cervix. DR ExpressionAtlas; E7ENL6; baseline and differential. DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro. DR CDD; cd00063; FN3; 1. DR CDD; cd00109; KU; 1. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.40.50.410; -; 9. DR Gene3D; 4.10.410.10; -; 1. DR InterPro; IPR008160; Collagen. DR InterPro; IPR003961; FN3_dom. DR InterPro; IPR036116; FN3_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR002223; Kunitz_BPTI. DR InterPro; IPR036880; Kunitz_BPTI_sf. DR InterPro; IPR020901; Prtase_inh_Kunz-CS. DR InterPro; IPR002035; VWF_A. DR InterPro; IPR036465; vWFA_dom_sf. DR Pfam; PF01391; Collagen; 3. DR Pfam; PF00014; Kunitz_BPTI; 1. DR Pfam; PF00092; VWA; 8. DR PRINTS; PR00759; BASICPTASE. DR SMART; SM00131; KU; 1. DR SMART; SM00327; VWA; 9. DR SUPFAM; SSF49265; SSF49265; 1. DR SUPFAM; SSF53300; SSF53300; 9. DR SUPFAM; SSF57362; SSF57362; 1. DR PROSITE; PS00280; BPTI_KUNITZ_1; 1. DR PROSITE; PS50279; BPTI_KUNITZ_2; 1. DR PROSITE; PS50853; FN3; 1. DR PROSITE; PS50234; VWFA; 9. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:E7ENL6, KW ECO:0000213|MaxQB:E7ENL6, ECO:0000213|PeptideAtlas:E7ENL6}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 2569 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003217310. FT DOMAIN 38 213 VWFA. {ECO:0000259|PROSITE:PS50234}. FT DOMAIN 230 402 VWFA. {ECO:0000259|PROSITE:PS50234}. FT DOMAIN 422 598 VWFA. {ECO:0000259|PROSITE:PS50234}. FT DOMAIN 626 797 VWFA. {ECO:0000259|PROSITE:PS50234}. FT DOMAIN 829 1002 VWFA. {ECO:0000259|PROSITE:PS50234}. FT DOMAIN 1032 1205 VWFA. {ECO:0000259|PROSITE:PS50234}. FT DOMAIN 1231 1417 VWFA. {ECO:0000259|PROSITE:PS50234}. FT DOMAIN 1794 1973 VWFA. {ECO:0000259|PROSITE:PS50234}. FT DOMAIN 2011 2207 VWFA. {ECO:0000259|PROSITE:PS50234}. FT DOMAIN 2383 2477 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 2504 2554 BPTI/Kunitz inhibitor. FT {ECO:0000259|PROSITE:PS50279}. SQ SEQUENCE 2569 AA; 278118 MW; AC1F756DB71A5986 CRC64; MRKHRHLPLV AVFCLFLSGF PTTHAQQQQA VIEVNKRDIV FLVDGSSALG LANFNAIRDF IAKVIQRLEI GQDLIQVAVA QYADTVRPEF YFNTHPTKRE VITAVRKMKP LDGSALYTGS ALDFVRNNLF TSSAGYRAAE GIPKLLVLIT GGKSLDEISQ PAQELKRSSI MAFAIGNKGA DQAELEEIAF DSSLVFIPAE FRAAPLQGML PGLLAPLRTL SGTPEESKRD ILFLFDGSAN LVGQFPVVRD FLYKIIDELN VKPEGTRIAV AQYSDDVKVE SRFDEHQSKP EILNLVKRMK IKTGKALNLG YALDYAQRYI FVKSAGSRIE DGVLQFLVLL VAGRSSDRVD GPASNLKQSG VVPFIFQAKN ADPAELEQIV LSPAFILAAE SLPKIGDLHP QIVNLLKSVH NGAPAPVSGE KDVVFLLDGS EGVRSGFPLL KEFVQRVVES LDVGQDRVRV AVVQYSDRTR PEFYLNSYMN KQDVVNAVRQ LTLLGGPTPN TGAALEFVLR NILVSSAGSR ITEGVPQLLI VLTADRSGDD VRNPSVVVKR GGAVPIGIGI GNADITEMQT ISFIPDFAVA IPTFRQLGTV QQVISERVTQ LTREELSRLQ PVLQPLPSPG VGGKRDVVFL IDGSQSAGPE FQYVRTLIER LVDYLDVGFD TTRVAVIQFS DDPKVEFLLN AHSSKDEVQN AVQRLRPKGG RQINVGNALE YVSRNIFKRP LGSRIEEGVP QFLVLISSGK SDDEVDDPAV ELKQFGVAPF TIARNADQEE LVKISLSPEY VFSVSTFREL PSLEQKLLTP ITTLTSEQIQ KLLASTRYPP PAVESDAADI VFLIDSSEGV RPDGFAHIRD FVSRIVRRLN IGPSKVRVGV VQFSNDVFPE FYLKTYRSQA PVLDAIRRLR LRGGSPLNTG KALEFVARNL FVKSAGSRIE DGVPQHLVLV LGGKSQDDVS RFAQVIRSSG IVSLGVGDRN IDRTELQTIT NDPRLVFTVR EFRELPNIEE RIMNSFGPSA ATPAPPGVDT PPPSRPEKKK ADIVFLLDGS INFRRDSFQE VLRFVSEIVD TVYEDGDSIQ VGLVQYNSDP TDEFFLKDFS TKRQIIDAIN KVVYKGGRHA NTKVGLEHLR VNHFVPEAGS RLDQRVPQIA FVITGGKSVE DAQDVSLALT QRGVKVFAVG VRNIDSEEVG KIASNSATAF RVGNVQELSE LSEQVLETLH DAMHETLCPG VTDAAKACNL DVILGFDGSR DQNVFVAQKG FESKVDAILN RISQMHRVSC SGGRSPTVRV SVVANTPSGP VEAFDFDEYQ PEMLEKFRNM RSQHPYVLTE DTLKVYLNKF RQSSPDSVKV VIHFTDGADG DLADLHRASE NLRQEGVRAL ILVGLERVVN LERLMHLEFG RGFMYDRPLR LNLLDLDYEL AEQLDNIAEK ACCGVPCKCS GQRGDRGPIG SIGPKGIPGE DGYRGYPGDE GGPGERGPPG VNGTQGFQGC PGQRGVKGSR GFPGEKGEVG EIGLDGLDGE DGDKGLPGSS GEKGNPGRRG DKGPRGEKGE RGDVGIRGDP GNPGQDSQER GPKGETGDLG PMGVPGRDGV PGGPGETGKN GGFGRRGPPG AKGNKGGPGQ PGFEGEQGTR GAQGPAGPAG PPGLIGEQGI SGPRGSGGAA GAPGERGRTG PLGRKGEPGE PGPKGGIGNR GPRGETGDDG RDGVGSEGRR GKKGERGFPG YPGPKGNPGE PGLNGTTGPK GIRGRRGNSG PPGIVGQKGD PGYPGPAGPK GNRGDSIDQC ALIQSIKDKC PFHGPLECPV FPTELAFALD TSEGVNQDTF GRMRDVVLSI VNDLTIAESN CPRGARVAVV TYNNEVTTEI RFADSKRKSV LLDKIKNLQV ALTSKQQSLE TAMSFVARNT FKRVRNGFLM RKVAVFFSNT PTRASPQLRE AVLKLSDAGI TPLFLTRQED RQLINALQIN NTAVGHALVL PAGRDLTDFL ENVLTCHVCL DICNIDPSCG FGSWRPSFRD RRAAGSDVDI DMAFILDSAE TTTLFQFNEM KKYIAYLVRQ LDMSPDPKAS QHFARVAVVQ HAPSESVDNA SMPPVKVEFS LTDYGSKEKL VDFLSRGMTQ LQGTRALGSA IEYTIENVFE SAPNPRDLKI VVLMLTGEVP EQQLEEAQRV ILQAKCKGYF FVVLGIGRKV NIKEVYTFAS EPNDVFFKLV DKSTELNEEP LMRFGRLLPS FVSSENAFYL SPDIRKQCDW FQGDQPTKNL VKFGHKQVNV PNNVTSSPTS NPVTTTKPVT TTKPVTTTTK PVTTTTKPVT IINQPSVKPA AAKPAPAKPV AAKPVATKMA TVRPPVAVKP ATAAKPVAAK PAAVRPPAAA AAKPVATKPE VPRPQAAKPA ATKPATTKPM VKMSREVQVF EITENSAKLH WERAEPPGPY FYDLTVTSAH DQSLVLKQNL TVTDRVIGGL LAGQTYHVAV VCYLRSQVRA TYHGSFSTKK SQPPPPQPAR SASSSTINLM VSTEPLALTE TDICKLPKDE GTCRDFILKW YYDPNTKSCA RFWYGGCGGN ENKFGSQKEC EKVCAPVLAK PGVISVMGT //