ID   E7ENI1_HUMAN            Unreviewed;       672 AA.
AC   E7ENI1;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-JAN-2019, entry version 58.
DE   RecName: Full=Lutropin-choriogonadotropic hormone receptor {ECO:0000256|RuleBase:RU361222};
GN   Name=LHCGR {ECO:0000256|RuleBase:RU361222,
GN   ECO:0000313|Ensembl:ENSP00000386033};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000386033, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000386033, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000386033}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Receptor for lutropin-choriogonadotropic hormone. The
CC       activity of this receptor is mediated by G proteins which activate
CC       adenylate cyclase. {ECO:0000256|RuleBase:RU361222}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361222}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361222}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       FSH/LSH/TSH subfamily. {ECO:0000256|RuleBase:RU361222}.
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DR   EMBL; AC073082; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC087816; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456667; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E7ENI1; -.
DR   jPOST; E7ENI1; -.
DR   PRIDE; E7ENI1; -.
DR   Ensembl; ENST00000405626; ENSP00000386033; ENSG00000138039.
DR   UCSC; uc061jap.1; human.
DR   EuPathDB; HostDB:ENSG00000138039.14; -.
DR   HGNC; HGNC:6585; LHCGR.
DR   OpenTargets; ENSG00000138039; -.
DR   eggNOG; KOG2087; Eukaryota.
DR   eggNOG; ENOG410XR1T; LUCA.
DR   GeneTree; ENSGT00940000157364; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000138039; Expressed in 67 organ(s), highest expression level in lower esophagus muscularis layer.
DR   ExpressionAtlas; E7ENI1; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004964; F:luteinizing hormone receptor activity; IEA:InterPro.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR002131; Gphrmn_rcpt_fam.
DR   InterPro; IPR026906; LRR_5.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002273; LSH_rcpt.
DR   InterPro; IPR034298; TSHR/LHCGR/FSHR.
DR   PANTHER; PTHR24372; PTHR24372; 2.
DR   Pfam; PF00001; 7tm_1; 1.
DR   Pfam; PF13306; LRR_5; 2.
DR   PRINTS; PR00373; GLYCHORMONER.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01144; LSHRECEPTOR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|RuleBase:RU361222};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   G-protein coupled receptor {ECO:0000256|RuleBase:RU361222};
KW   Leucine-rich repeat {ECO:0000256|SAAS:SAAS00619388};
KW   Membrane {ECO:0000256|RuleBase:RU361222};
KW   Receptor {ECO:0000256|RuleBase:RU361222};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00619387};
KW   Signal {ECO:0000256|RuleBase:RU361222};
KW   Transducer {ECO:0000256|RuleBase:RU361222};
KW   Transmembrane {ECO:0000256|RuleBase:RU361222};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361222}.
FT   SIGNAL        1     24       {ECO:0000256|RuleBase:RU361222}.
FT   CHAIN        25    672       Lutropin-choriogonadotropic hormone
FT                                receptor.
FT                                {ECO:0000256|RuleBase:RU361222}.
FT                                /FTId=PRO_5005128325.
FT   TRANSMEM    337    358       Helical. {ECO:0000256|RuleBase:RU361222}.
FT   TRANSMEM    370    391       Helical. {ECO:0000256|RuleBase:RU361222}.
FT   TRANSMEM    415    435       Helical. {ECO:0000256|RuleBase:RU361222}.
FT   TRANSMEM    456    479       Helical. {ECO:0000256|RuleBase:RU361222}.
FT   TRANSMEM    499    524       Helical. {ECO:0000256|RuleBase:RU361222}.
FT   TRANSMEM    545    567       Helical. {ECO:0000256|RuleBase:RU361222}.
FT   TRANSMEM    579    599       Helical. {ECO:0000256|RuleBase:RU361222}.
FT   DOMAIN      349    596       G_PROTEIN_RECEP_F1_2.
FT                                {ECO:0000259|PROSITE:PS50262}.
SQ   SEQUENCE   672 AA;  75521 MW;  96450DFF46801BFA CRC64;
     MKQRFSALQL LKLLLLLQPP LPRALREALC PEPCNCVPDG ALRCPGPTAG LTRLSLAYLP
     VKVIPSQAFR GLNEVIKIEI SQIDSLERIE ANAFDNLLNL SEILIQNTKN LRYIEPGAFI
     NLPRLKYLSI CNTGIRKFPD VTKVFSSESN FILEICDNLH ITTIPGNAFQ GMNNESVTLK
     LYGNGFEEVQ SHAFNGTTLT SLELKENVHL EKMHNGAFRG ATGPKTLDIS STKLQALPSY
     GLESIQRLIA TSSYSLKKLP SRETFVNLLE ATLTYPSHCC AFRNLPTKDY SSMLAESELS
     GWDYEYGFCL PKTPRCAPEP DAFNPCEDIM GYDFLRVLIW LINILAIMGN MTVLFVLLTS
     RYKLTVPRFL MCNLSFADFC MGLYLLLIAS VDSQTKGQYY NHAIDWQTGS GCSTAGFFTV
     FASELSVYTL TVITLERWHT ITYAIHLDQK LRLRHAILIM LGGWLFSSLI AMLPLVGVSN
     YMKVSICFPM DVETTLSQVY ILTILILNVV AFFIICACYI KIYFAVRNPE LMATNKDTKI
     AKKMAILIFT DFTCMAPISF FAISAAFKVP LITVTNSKVL LVLFYPINSC ANPFLYAIFT
     KTFQRDFFLL LSKFGCCKRR AELYRRKDFS AYTSNCKNGF TGSNKPSQST LKLSTLHCQG
     TALLDKTRYT EC
//