ID   E7ENH0_HUMAN            Unreviewed;       326 AA.
AC   E7ENH0;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 2.
DT   05-DEC-2018, entry version 45.
DE   SubName: Full=Pregnancy-specific beta-1-glycoprotein 8 {ECO:0000313|Ensembl:ENSP00000386090};
GN   Name=PSG8 {ECO:0000313|Ensembl:ENSP00000386090};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000386090, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000386090, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000386090}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC004603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC004610; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC004654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005238; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E7ENH0; -.
DR   PeptideAtlas; E7ENH0; -.
DR   PRIDE; E7ENH0; -.
DR   Ensembl; ENST00000401467; ENSP00000386090; ENSG00000124467.
DR   UCSC; uc060zin.1; human.
DR   EuPathDB; HostDB:ENSG00000124467.18; -.
DR   HGNC; HGNC:9525; PSG8.
DR   OpenTargets; ENSG00000124467; -.
DR   GeneTree; ENSGT00940000153087; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000124467; Expressed in 19 organ(s), highest expression level in placenta.
DR   ExpressionAtlas; E7ENH0; baseline and differential.
DR   Gene3D; 2.60.40.10; -; 3.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF13895; Ig_2; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 3.
DR   SMART; SM00408; IGc2; 2.
DR   SUPFAM; SSF48726; SSF48726; 3.
DR   PROSITE; PS50835; IG_LIKE; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     34       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        35    326       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003217470.
FT   DOMAIN      147    234       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      242    317       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   326 AA;  36773 MW;  AEBDB81354965247 CRC64;
     MGPLSAPPCT QHIKWKGVLL TASLLNFWNP PTTAQVTIEA QPTKVSEGKD VLLLVHNLPQ
     NLTGYIWYKG QIRDLYHYIT SYVVDGQIII YGPAYSGRET IYSNASLLIQ NVTQEDAGSY
     TLHIIMGGDE NRGVTGHFTF TLYPKLPKPY ITINNLKPRE NKDVLNFTCE PKSENYTYIW
     WLNGQSLPVS PRVKRPIENR ILILPSVTRN ETGPYQCEIR DQYGGIRSYP VTLNVLYGPD
     LPRIYPSFTY YRSGEVLYLS CSADSNPPAQ YSWTINGKFQ LSGQKLFIPQ ITTKHSGLYA
     CSVRNSATGK ESSKSMTVKV SDWTLP
//