ID E7ENE5_HUMAN Unreviewed; 377 AA. AC E7ENE5; DT 08-MAR-2011, integrated into UniProtKB/TrEMBL. DT 08-MAR-2011, sequence version 1. DT 05-DEC-2018, entry version 66. DE SubName: Full=Acetylcholine receptor subunit alpha {ECO:0000313|Ensembl:ENSP00000386611}; GN Name=CHRNA1 {ECO:0000313|Ensembl:ENSP00000386611}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000386611, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000386611, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [2] {ECO:0000213|PubMed:19690332} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:ra46-RA46(2009). RN [3] {ECO:0000313|Ensembl:ENSP00000386611} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell CC membrane {ECO:0000256|SAAS:SAAS00569352}; Multi-pass membrane CC protein {ECO:0000256|SAAS:SAAS00569352}. Cell membrane CC {ECO:0000256|SAAS:SAAS00569391}; Multi-pass membrane protein CC {ECO:0000256|SAAS:SAAS00569391}. CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) CC family. {ECO:0000256|RuleBase:RU000687, CC ECO:0000256|SAAS:SAAS00978283}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC018890; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; E7ENE5; -. DR PRIDE; E7ENE5; -. DR Ensembl; ENST00000409219; ENSP00000386611; ENSG00000138435. DR UCSC; uc061pvt.1; human. DR EuPathDB; HostDB:ENSG00000138435.14; -. DR HGNC; HGNC:1955; CHRNA1. DR OpenTargets; ENSG00000138435; -. DR eggNOG; KOG3645; Eukaryota. DR eggNOG; ENOG410XQGR; LUCA. DR GeneTree; ENSGT00940000156851; -. DR Proteomes; UP000005640; Chromosome 2. DR Bgee; ENSG00000138435; Expressed in 84 organ(s), highest expression level in quadriceps femoris. DR ExpressionAtlas; E7ENE5; baseline and differential. DR GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IDA:HPA. DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell. DR GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR Gene3D; 2.70.170.10; -; 1. DR InterPro; IPR006202; Neur_chan_lig-bd. DR InterPro; IPR036734; Neur_chan_lig-bd_sf. DR InterPro; IPR006201; Neur_channel. DR InterPro; IPR036719; Neuro-gated_channel_TM_sf. DR InterPro; IPR006029; Neurotrans-gated_channel_TM. DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS. DR InterPro; IPR002394; Nicotinic_acetylcholine_rcpt. DR PANTHER; PTHR18945; PTHR18945; 2. DR Pfam; PF02931; Neur_chan_LBD; 1. DR Pfam; PF02932; Neur_chan_memb; 1. DR PRINTS; PR00254; NICOTINICR. DR PRINTS; PR00252; NRIONCHANNEL. DR SUPFAM; SSF63712; SSF63712; 1. DR SUPFAM; SSF90112; SSF90112; 1. DR TIGRFAMs; TIGR00860; LIC; 1. DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1. PE 1: Evidence at protein level; KW Cell junction {ECO:0000256|SAAS:SAAS00103558}; KW Cell membrane {ECO:0000256|SAAS:SAAS00081553}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00103544}; KW Ion channel {ECO:0000256|SAAS:SAAS00032596}; KW Ion transport {ECO:0000256|SAAS:SAAS00032596}; KW Ligand-gated ion channel {ECO:0000256|SAAS:SAAS00032596}; KW Membrane {ECO:0000256|SAAS:SAAS00081553, KW ECO:0000256|SAAS:SAAS00103558, ECO:0000256|SAAS:SAAS00978768, KW ECO:0000256|SAM:Phobius}; KW Postsynaptic cell membrane {ECO:0000256|SAAS:SAAS00103558}; KW Receptor {ECO:0000256|SAAS:SAAS00079193}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Synapse {ECO:0000256|SAAS:SAAS00103558}; KW Transmembrane {ECO:0000256|SAAS:SAAS00978768, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00978768, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00032596}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 377 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003219420. FT TRANSMEM 232 255 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 267 285 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 297 316 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 349 371 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 24 230 Neur_chan_LBD. FT {ECO:0000259|Pfam:PF02931}. FT DOMAIN 238 336 Neur_chan_memb. FT {ECO:0000259|Pfam:PF02932}. SQ SEQUENCE 377 AA; 42806 MW; E252CDDAAE65CA40 CRC64; MEPWPLLLLF SLCSAGLVLG SEHETRLVAK LFKDYSSVVR PVEDHRQVVE VTVGLQLIQL INVDEVNQIV TTNVRLKQQW VDYNLKWNPD DYGGVKKIHI PSEKIWRPDL VLYNNADGDF AIVKFTKVLL QYTGHITWTP PAIFKSYCEI IVTHFPFDEQ NCSMKLGTWT YDGSVVAINP ESDQPDLSNF MESGEWVIKE SRGWKHSVTY SCCPDTPYLD ITYHFVMQRL PLYFIVNVII PCLLFSFLTG LVFYLPTDSG EKMTLSISVL LSLTVFLLVI VELIPSTSSA VPLIGKYMLF TMVFVIASII ITVIVINTHH RSPSTHVMPN WVRKAAAEWK YVAMVMDHIL LGVFMLVCII GTLAVFAGRL IELNQQG //