ID   E7END4_HUMAN            Unreviewed;       697 AA.
AC   E7END4;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-JAN-2019, entry version 57.
DE   SubName: Full=Lysyl oxidase homolog 3 {ECO:0000313|Ensembl:ENSP00000386696};
GN   Name=LOXL3 {ECO:0000313|Ensembl:ENSP00000386696};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000386696, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000386696, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000386696}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
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DR   EMBL; AC005033; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E7END4; -.
DR   jPOST; E7END4; -.
DR   PeptideAtlas; E7END4; -.
DR   PRIDE; E7END4; -.
DR   Ensembl; ENST00000409549; ENSP00000386696; ENSG00000115318.
DR   UCSC; uc010ffm.3; human.
DR   EuPathDB; HostDB:ENSG00000115318.11; -.
DR   HGNC; HGNC:13869; LOXL3.
DR   OpenTargets; ENSG00000115318; -.
DR   GeneTree; ENSGT00940000158157; -.
DR   ChiTaRS; LOXL3; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000115318; Expressed in 160 organ(s), highest expression level in tibia.
DR   ExpressionAtlas; E7END4; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0016641; F:oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor; IEA:InterPro.
DR   GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR   Gene3D; 3.10.250.10; -; 4.
DR   InterPro; IPR001695; Lysyl_oxidase.
DR   InterPro; IPR019828; Lysyl_oxidase_CS.
DR   InterPro; IPR001190; SRCR.
DR   InterPro; IPR017448; SRCR-like_dom.
DR   InterPro; IPR036772; SRCR-like_dom_sf.
DR   Pfam; PF01186; Lysyl_oxidase; 1.
DR   Pfam; PF00530; SRCR; 3.
DR   PRINTS; PR00074; LYSYLOXIDASE.
DR   PRINTS; PR00258; SPERACTRCPTR.
DR   SMART; SM00202; SR; 3.
DR   SUPFAM; SSF56487; SSF56487; 4.
DR   PROSITE; PS00926; LYSYL_OXIDASE; 1.
DR   PROSITE; PS00420; SRCR_1; 1.
DR   PROSITE; PS50287; SRCR_2; 4.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00196,
KW   ECO:0000256|SAAS:SAAS00873970};
KW   Proteomics identification {ECO:0000213|MaxQB:E7END4,
KW   ECO:0000213|PeptideAtlas:E7END4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    697       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003217468.
FT   DOMAIN       44    145       SRCR. {ECO:0000259|PROSITE:PS50287}.
FT   DOMAIN      169    282       SRCR. {ECO:0000259|PROSITE:PS50287}.
FT   DOMAIN      307    407       SRCR. {ECO:0000259|PROSITE:PS50287}.
FT   DOMAIN      431    469       SRCR. {ECO:0000259|PROSITE:PS50287}.
FT   DISULFID     70    134       {ECO:0000256|PROSITE-ProRule:PRU00196}.
FT   DISULFID     83    144       {ECO:0000256|PROSITE-ProRule:PRU00196}.
FT   DISULFID    114    124       {ECO:0000256|PROSITE-ProRule:PRU00196}.
FT   DISULFID    248    258       {ECO:0000256|PROSITE-ProRule:PRU00196}.
FT   DISULFID    332    396       {ECO:0000256|PROSITE-ProRule:PRU00196}.
FT   DISULFID    345    406       {ECO:0000256|PROSITE-ProRule:PRU00196}.
FT   DISULFID    376    386       {ECO:0000256|PROSITE-ProRule:PRU00196}.
FT   DISULFID    436    446       {ECO:0000256|PROSITE-ProRule:PRU00196}.
SQ   SEQUENCE   697 AA;  77198 MW;  EDBC34B58E53044F CRC64;
     MRPVSVWQWS PWGLLLCLLC SSCLGSPSPS TGPEKKAGSQ GLRFRLAGFP RKPYEGRVEI
     QRAGEWGTIC DDDFTLQAAH ILCRELGFTE ATGWTHSAKY GPGTGRIWLD NLSCSGTEQS
     VTECASRGWG NSDCTHDEDA GVICKDQRLP GFSDSNVIEV EHHLQVEEVR IRPAVGWGRR
     PLPVTEGLVE VRLPDGWSQV CDKGWSAHNS HVVCGMLGFP SEKRVNAAFY RLLAQRQQHS
     FGLHGVACVG TEAHLSLCSL EFYRANDTAR CPGGGPAVVS CVPGPVYAAS SGQKKQQQSK
     PQGEARVRLK GGAHPGEGRV EVLKASTWGT VCDRKWDLHA ASVVCRELGF GSAREALSGA
     RMGQGMGAIH LSEVRCSGQE LSLWKCPHKN ITAEDCSHSQ DAGVRCNLPY TGAETRETWY
     WDSGNITEVV MSGVRCTGTE LSLDQCAHHG THITCKRTGT RFTAGVICSE TASDLLLHSA
     LVQETAYIED RPLHMLYCAA EENCLASSAR SANWPYGHRR LLRFSSQIHN LGRADFRPKA
     GRHSWVWHEC HGHYHSMDIF THYDILTPNG TKVAEGHKAS FCLEDTECQE DVSKRYECAN
     FGEQGITVGC WDLYRHDIDC QWIDITDVKP GNYILQVVIN PNFEVAESDF TNNAMKCNCK
     YDGHRIWVHN CHIGDAFSEE ANRRFERYPG QTSNQII
//