ID   E7EN65_HUMAN            Unreviewed;       714 AA.
AC   E7EN65;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-JAN-2019, entry version 50.
DE   SubName: Full=Elastin {ECO:0000313|Ensembl:ENSP00000403162};
GN   Name=ELN {ECO:0000313|Ensembl:ENSP00000403162};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000403162, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000403162, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000403162}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC005056; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001265846.1; NM_001278917.1.
DR   UniGene; Hs.647061; -.
DR   ProteinModelPortal; E7EN65; -.
DR   Allergome; 11040; Hom s Elastin.
DR   jPOST; E7EN65; -.
DR   PeptideAtlas; E7EN65; -.
DR   PRIDE; E7EN65; -.
DR   Ensembl; ENST00000458204; ENSP00000403162; ENSG00000049540.
DR   GeneID; 2006; -.
DR   UCSC; uc003tzx.5; human.
DR   CTD; 2006; -.
DR   EuPathDB; HostDB:ENSG00000049540.16; -.
DR   HGNC; HGNC:3327; ELN.
DR   OpenTargets; ENSG00000049540; -.
DR   eggNOG; ENOG410IZT8; Eukaryota.
DR   eggNOG; ENOG4111817; LUCA.
DR   GeneTree; ENSGT00730000111510; -.
DR   OrthoDB; 930292at2759; -.
DR   ChiTaRS; ELN; human.
DR   GenomeRNAi; 2006; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000049540; Expressed in 181 organ(s), highest expression level in thoracic aorta.
DR   ExpressionAtlas; E7EN65; baseline and differential.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro.
DR   GO; GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro.
DR   InterPro; IPR003979; Tropoelastin.
DR   PANTHER; PTHR24018; PTHR24018; 3.
DR   PRINTS; PR01500; TROPOELASTIN.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:E7EN65,
KW   ECO:0000213|PeptideAtlas:E7EN65};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     26       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        27    714       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003217306.
SQ   SEQUENCE   714 AA;  61923 MW;  0159DB68B68BAAFB CRC64;
     MAGLTAAAPR PGVLLLLLSI LHPSRPGGVP GAIPGGVPGG VFYPALGPGG KPLKPVPGGL
     AGAGLGAGLG AFPAVTFPGA LVPGGVADAA AAYKAAKAGA GLGGVPGVGG LGVSAGAVVP
     QPGAGVKPGK VPGVGLPGVY PGGVLPGARF PGVGVLPGVP TGAGVKPKAP GVGGAFAGIP
     GVGPFGGPQP GVPLGYPIKA PKLPGGYGLP YTTGKLPYGY GPGGVAGAAG KAGYPTGTGV
     GPQAAAAAAA KAAAKFGAGA AGVLPGVGGA GVPGVPGAIP GIGGIAGVGT PAAAAAAAAA
     AKAAKYGAAA GLVPGGPGFG PGVVGVPGAG VPGVGVPGAG IPVVPGAGIP GAAVPGVVSP
     EAAAKAAAKA AKYGARPGVG VGGIPTYGVG AGGFPGFGVG VGGIPGVAGV PGVGGVPGVG
     GVPGVGISPE AQAAAAAKAA KYGVGTPAAA AAKAAAKAAQ FGLVPGVGVA PGVGVAPGVG
     VAPGVGLAPG VGVAPGVGVA PGVGVAPGIG PGGVAAAAKS AAKVAAKAQL RAAAGLGAGI
     PGLGVGVGVP GLGVGAGVPG LGVGAGVPGF GAVPGALAAA KAAKYGAAVP GVLGGLGALG
     GVGIPGGVVG AGPAAAAAAA KAAAKAAQFG LVGAAGLGGL GVGGLGVPGV GGLGGIPPAA
     AAKAAKYGAA GLGGVLGGAG QFPLGGVAAR PGFGLSPIFP GGACLGKACG RKRK
//