ID   E7EN24_HUMAN            Unreviewed;       580 AA.
AC   E7EN24;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-JAN-2019, entry version 56.
DE   SubName: Full=Cadherin-17 {ECO:0000313|Ensembl:ENSP00000392811};
GN   Name=CDH17 {ECO:0000313|Ensembl:ENSP00000392811};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000392811, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000392811, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000392811}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AP003351; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP003478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E7EN24; -.
DR   jPOST; E7EN24; -.
DR   MaxQB; E7EN24; -.
DR   PeptideAtlas; E7EN24; -.
DR   PRIDE; E7EN24; -.
DR   Ensembl; ENST00000441892; ENSP00000392811; ENSG00000079112.
DR   UCSC; uc011lgo.2; human.
DR   EuPathDB; HostDB:ENSG00000079112.9; -.
DR   HGNC; HGNC:1756; CDH17.
DR   OpenTargets; ENSG00000079112; -.
DR   GeneTree; ENSGT00940000157655; -.
DR   ChiTaRS; CDH17; human.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000079112; Expressed in 86 organ(s), highest expression level in colonic mucosa.
DR   ExpressionAtlas; E7EN24; baseline and differential.
DR   GO; GO:0030054; C:cell junction; IDA:HPA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IDA:HPA.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   Pfam; PF00028; Cadherin; 3.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 4.
DR   SUPFAM; SSF49313; SSF49313; 5.
DR   PROSITE; PS00232; CADHERIN_1; 2.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|SAAS:SAAS00020193};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00616217};
KW   Proteomics identification {ECO:0000213|MaxQB:E7EN24,
KW   ECO:0000213|PeptideAtlas:E7EN24};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00436611};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00616217};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00616217}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    580       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003217305.
FT   DOMAIN       39    124       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      148    233       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      258    351       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      374    451       CA. {ECO:0000259|SMART:SM00112}.
SQ   SEQUENCE   580 AA;  64164 MW;  F921940347CA8C5E CRC64;
     MILQAHLHSL CLLMLYLATG YGQEGKFSGP LKPMTFSIYE GQEPSQIIFQ FKANPPAVTF
     ELTGETDNIF VIEREGLLYY NRALDRETRS THNLQVAALD ANGIIVEGPV PITIKVKDIN
     DNRPTFLQSK YEGSVRQNSR PGNSIGTLTA HDRDEENTAN SFLNYRIVEQ TPKLPMDGLF
     LIQTYAGMLQ LAKQSLKKQD TPQYNLTIEV SDKDFKTLCF VQINVIDIND QIPIFEKSDY
     GNLTLAEDTN IGSTILTIQA TDADEPFTGS SKILYHIIKG DSEGRLGVDT DPHTNTGYVI
     IKKPLDFETA AVSNIVFKAE NPEPLVFGVK YNASSFAKFT LIVTDVNEAP QFSQHVFQAK
     VSEDVAIGTK VGNVTAKDPE GLDISYSLRG DTRGWLKIDH VTGEIFSVAP LDREAGSPYR
     VQVVATEVGG SSLSSVSEFH LILMDVNDNP PRLAKDYTGL FFCHPLSAPG SLIFEATDDD
     QHLFRGPHFT FSLGSGSLQN DWEVSKINGT HARLSTRHTE FEEREYVVLI RINDGGRPPL
     EGIVSLPGII LAVVFIRIKK DKGKDNVESA QASEVKPLRS
//