ID   E7EMU6_HUMAN            Unreviewed;       372 AA.
AC   E7EMU6;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   13-FEB-2019, entry version 48.
DE   SubName: Full=UDP-glucose:glycoprotein glucosyltransferase 2 {ECO:0000313|Ensembl:ENSP00000380743};
GN   Name=UGGT2 {ECO:0000313|Ensembl:ENSP00000380743};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000380743, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000380743, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057823; DOI=10.1038/nature02379;
RA   Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA   Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E.,
RA   Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.,
RA   Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R.,
RA   Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S.,
RA   Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M.,
RA   Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J.,
RA   Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E.,
RA   Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L.,
RA   Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J.,
RA   Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S.,
RA   Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J.,
RA   Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M.,
RA   King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A.,
RA   Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S.,
RA   Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA   Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S.,
RA   Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A.,
RA   Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L.,
RA   Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.,
RA   Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.;
RT   "The DNA sequence and analysis of human chromosome 13.";
RL   Nature 428:522-528(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000380743}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AL136104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL158192; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL162500; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL607038; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EPD; E7EMU6; -.
DR   jPOST; E7EMU6; -.
DR   MaxQB; E7EMU6; -.
DR   PeptideAtlas; E7EMU6; -.
DR   PRIDE; E7EMU6; -.
DR   Ensembl; ENST00000397618; ENSP00000380743; ENSG00000102595.
DR   UCSC; uc001vmv.4; human.
DR   EuPathDB; HostDB:ENSG00000102595.18; -.
DR   HGNC; HGNC:15664; UGGT2.
DR   OpenTargets; ENSG00000102595; -.
DR   eggNOG; KOG1879; Eukaryota.
DR   eggNOG; ENOG410XRK6; LUCA.
DR   GeneTree; ENSGT00390000004600; -.
DR   ChiTaRS; UGGT2; human.
DR   Proteomes; UP000005640; Chromosome 13.
DR   Bgee; ENSG00000102595; Expressed in 207 organ(s), highest expression level in intestine.
DR   ExpressionAtlas; E7EMU6; baseline and differential.
DR   GO; GO:0003980; F:UDP-glucose:glycoprotein glucosyltransferase activity; IEA:InterPro.
DR   GO; GO:0006486; P:protein glycosylation; IEA:InterPro.
DR   InterPro; IPR009448; UDP-g_GGtrans.
DR   InterPro; IPR040693; UGGT_TRXL_1.
DR   InterPro; IPR040694; UGGT_TRXL_2.
DR   PANTHER; PTHR11226; PTHR11226; 1.
DR   Pfam; PF18400; Thioredoxin_12; 1.
DR   Pfam; PF18401; Thioredoxin_13; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:E7EMU6,
KW   ECO:0000213|PeptideAtlas:E7EMU6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     27       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        28    372       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003218959.
FT   DOMAIN       45    225       Thioredoxin_12.
FT                                {ECO:0000259|Pfam:PF18400}.
FT   DOMAIN      297    344       Thioredoxin_13.
FT                                {ECO:0000259|Pfam:PF18401}.
SQ   SEQUENCE   372 AA;  42534 MW;  4A032CD081F20A30 CRC64;
     MAPAKATNVV RLLLGSTALW LSQLGSGTVA ASKSVTAHLA AKWPETPLLL EASEFMAEES
     NEKFWQFLET VQELAIYKQT ESDYSYYNLI LKKAGQFLDN LHINLLKFAF SIRAYSPAIQ
     MFQQIAADEP PPDGCNAFVV IHKKHTCKIN EIKKLLKKAA SRTRPYLFKG DHKFPTNKEN
     LPVVILYAEM GTRTFSAFHK VLSEKAQNEE ILYVLRHYIQ KPSSRKMYLS GYGVELAIKS
     TEYKALDDTQ VKTVTNTTVE DETETNEVQG FLFGKLKEIY SDLRDNLTAF QKYLIESNKQ
     MMPLKVWELQ DLSFQAASQI MSAPVYDSIK LMKDISQNFP IKARLRMNIL ICLFQSTLNV
     KNLRSRHLYN KT
//