ID   PRS44_HUMAN             Reviewed;         344 AA.
AC   E7EML9;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   14-DEC-2011, sequence version 3.
DT   16-JAN-2019, entry version 41.
DE   RecName: Full=Serine protease 44;
DE            EC=3.4.21.-;
DE   AltName: Full=Testis serine protease 4;
DE            Short=TESSP-4;
DE   Flags: Precursor;
GN   Name=PRSS44; Synonyms=TESSP4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00274}.
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DR   EMBL; AC109583; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E7EML9; -.
DR   SMR; E7EML9; -.
DR   BioMuta; HGNC:37324; -.
DR   PRIDE; E7EML9; -.
DR   ProteomicsDB; 16969; -.
DR   GeneCards; PRSS44; -.
DR   HGNC; HGNC:37324; PRSS44.
DR   neXtProt; NX_E7EML9; -.
DR   InParanoid; E7EML9; -.
DR   PhylomeDB; E7EML9; -.
DR   PRO; PR:E7EML9; -.
DR   Proteomes; UP000005640; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR   GO; GO:0007281; P:germ cell development; IBA:GO_Central.
DR   GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR   GO; GO:0007283; P:spermatogenesis; IBA:GO_Central.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Disulfide bond; Glycoprotein; Hydrolase; Protease;
KW   Reference proteome; Secreted; Serine protease; Signal.
FT   SIGNAL        1     27       {ECO:0000255}.
FT   CHAIN        28    344       Serine protease 44.
FT                                /FTId=PRO_0000413698.
FT   DOMAIN       97    332       Peptidase S1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00274}.
FT   ACT_SITE    137    137       Charge relay system. {ECO:0000250}.
FT   ACT_SITE    184    184       Charge relay system. {ECO:0000250}.
FT   ACT_SITE    284    284       Charge relay system. {ECO:0000250}.
FT   CARBOHYD    227    227       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID    122    138       {ECO:0000255|PROSITE-ProRule:PRU00274}.
FT   DISULFID    218    290       {ECO:0000255|PROSITE-ProRule:PRU00274}.
FT   DISULFID    249    270       {ECO:0000255|PROSITE-ProRule:PRU00274}.
FT   DISULFID    280    308       {ECO:0000255|PROSITE-ProRule:PRU00274}.
SQ   SEQUENCE   344 AA;  36995 MW;  28EEE9E5C179B36D CRC64;
     MASQSGSSLG LLAWFLLLQP WLEEARAGRV GAQGGVALLF PSALPSGPGG QDPGASGWEP
     PPVGAPGSPA APQSRGNAVR PASVLLPSAC GQRTSRITGG LPAPDRKWPW QVSLQTSNRH
     ICGGSLIARH WVLTAAHCIS GHLEYTVKLG DTNVHHRSKT ALVVPVRDVV IHRYFTSPGI
     IENDIALALL DFPVNYSTHI QLVCLPEQAF MVQAGTNCWV TGWGKVNETE KIVTEPQEAE
     LSIILHDKCN EVLKEKIRMR SEMVKKGTIC GYNDQGKDAC QGDSGGPLVC ELNGTWVQVG
     IVSWGIGCGR KGYPGVYTEV SFYKKWIIDH LRQASCLNSK TSSS
//