ID   E7EMG0_HUMAN            Unreviewed;      1915 AA.
AC   E7EMG0;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-JAN-2019, entry version 63.
DE   SubName: Full=Protocadherin-15 {ECO:0000313|Ensembl:ENSP00000378820};
GN   Name=PCDH15 {ECO:0000313|Ensembl:ENSP00000378820};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000378820, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000378820, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA   Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA   Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA   Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA   Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA   Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA   Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA   Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA   Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA   Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA   Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA   Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA   Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA   Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA   Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA   Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T.,
RA   Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000378820}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC013737; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC016817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC024073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC027671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL353784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL360214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL365496; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL391356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001136239.1; NM_001142767.1.
DR   UniGene; Hs.280209; -.
DR   ProteinModelPortal; E7EMG0; -.
DR   MaxQB; E7EMG0; -.
DR   PRIDE; E7EMG0; -.
DR   Ensembl; ENST00000395432; ENSP00000378820; ENSG00000150275.
DR   GeneID; 65217; -.
DR   UCSC; uc010qhw.1; human.
DR   CTD; 65217; -.
DR   EuPathDB; HostDB:ENSG00000150275.17; -.
DR   HGNC; HGNC:14674; PCDH15.
DR   OpenTargets; ENSG00000150275; -.
DR   eggNOG; KOG3594; Eukaryota.
DR   eggNOG; ENOG410XQHI; LUCA.
DR   GeneTree; ENSGT00940000156675; -.
DR   OrthoDB; 21247at2759; -.
DR   ChiTaRS; PCDH15; human.
DR   GenomeRNAi; 65217; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; ENSG00000150275; Expressed in 67 organ(s), highest expression level in corpus callosum.
DR   ExpressionAtlas; E7EMG0; baseline and differential.
DR   Genevisible; E7EMG0; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0032420; C:stereocilium; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   GO; GO:0048839; P:inner ear development; IEA:InterPro.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:InterPro.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR030718; Protocadherin-15.
DR   PANTHER; PTHR24028:SF11; PTHR24028:SF11; 3.
DR   Pfam; PF00028; Cadherin; 7.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 10.
DR   SUPFAM; SSF49313; SSF49313; 9.
DR   PROSITE; PS00232; CADHERIN_1; 3.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|SAAS:SAAS00020193};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00616217, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:E7EMG0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00436611};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00616217,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00616217,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     26       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        27   1915       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003219413.
FT   TRANSMEM   1339   1362       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       64    145       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      267    356       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      389    470       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      494    576       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      601    678       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      702    780       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      804    887       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      911    997       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN     1018   1105       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN     1129   1213       CA. {ECO:0000259|SMART:SM00112}.
SQ   SEQUENCE   1915 AA;  211325 MW;  99E83EAC042D3CF9 CRC64;
     MFRQFYLWTC LASGIILGSL FEICLGQYDD DCKLARGGPP ATIVAIDEES RNGTILVDNM
     LIKGTAGGPD PTIELSLKDN VDYWVLMDPV KQMLFLNSTG RVLDRDPPMN IHSIVVQVQC
     INKKVGTIIY HEVRIVVRDR NDNSPTFKHE SYYATVNELT PVGTTIFTGF SGDNGATDID
     DGPNGQIEYV IQYNPDDPDR AQNLNERRTT TTTLTVDVLD GDDLGPMFLP CVLVPNTRDC
     RPLTYQAAIP ELRTPEELNP IIVTPPIQAI DQDRNIQPPS DRPGILYSIL VGTPEDYPRF
     FHMHPRTAEL SLLEPVNRDF HQKFDLVIKA EQDNGHPLPA FAGLHIEILD ENNQSPYFTM
     PSYQGYILES APVGATISDS LNLTSPLRIV ALDKDIEDTK DPELHLFLND YTSVFTVTQT
     GITRYLTLLQ PVDREEQQTY TFSITAFDGV QESEPVIVNI QVMDANDNTP TFPEISYDVY
     VYTDMRPGDS VIQLTAVDAD EGSNGEITYE ILVGAQGDFI INKTTGLITI APGVEMIVGR
     TYALTVQAAD NAPPAERRNS ICTVYIEVLP PNNQSPPRFP QLMYSLEISE AMRVGAVLLN
     LQATDREGDS ITYAIENGDP QRVFNLSETT GILTLGKALD RESTDRYILI ITASDGRPDG
     TSTATVNIVV TDVNDNAPVF DPYLPRNLSV VEEEANAFVG QVKATDPDAG INGQVHYSLG
     NFNNLFRITS NGSIYTAVKL NREVRDYYEL VVVATDGAVH PRHSTLTLAI KVLDIDDNSP
     VFTNSTYTVL VEENLPAGTT ILQIEAKDVD LGANVSYRIR SPEVKHFFAL HPFTGELSLL
     RSLDYEAFPD QEASITFLVE AFDIYGTMPP GIATVTVIVK DMNDYPPVFS KRIYKGMVAP
     DAVKGTPITT VYAEDADPPG LPASRVRYRV DDVQFPYPAS IFEVEEDSGR VITRVNLNEE
     PTTIFKLVVV AFDDGEPVMS SSATVKILVL HPGEIPRFTQ EEYRPPPVSE LATKGTMVGV
     ISAAAINQSI VYSIVSGNEE DTFGINNITG VIYVNGPLDY ETRTSYVLRV QADSLEVVLA
     NLRVPSKSNT AKVYIEIQDE NNHPPVFQKK FYIGGVSEDA RMFTSVLRVK ATDKDTGNYS
     VMAYRLIIPP IKEGKEGFVV ETYTGLIKTA MLFHNMRRSY FKFQVIATDD YGKGLSGKAD
     VLVSVVNQLD MQVIVSNVPP TLVEKKIEDL TEILDRYVQE QIPGAKVVVE SIGARRHGDA
     FSLEDYTKCD LTVYAIDPQT NRAIDRNELF KFLDGKLLDI NKDFQPYYGE GGRILEIRTP
     EAVTSIKKRG ESLGYTEGAL LALAFIIILC CIPAILVVLV SYRQRQAECT KTARIQAALP
     AAKPAVPAPA PVAAPPPPPP PPPGAHLYEE LGDSSILFLL YHFQQSRGNN SVSEDRKHQQ
     VVMPFSSNTI EAHKSAHVDG SLKSNKLKSA RKFTFLSDED DLSAHNPLYK ENISQVSTNS
     DISQRTDFVD PFSPKIQAKS KSLRGPREKI QRLWSQSVSL PRRLMRKVPN RPEIIDLQQW
     QGTRQKAENE NTGICTNKRG SSNPLLTTEE ANLTEKEEIR QGETLMIEGT EQLKSLSSDS
     SFCFPRPHFS FSTLPTVSRT VELKSEPNVI SSPAECSLEL SPSRPCVLHS SLSRRETPIC
     MLPIETERNI FENFAHPPNI SPSACPLPPP PPISPPSPPP APAPLAPPPD ISPFSLFCPP
     PSPPSIPLPL PPPTFFPLSV STSGPPTPPL LPPFPTPLPP PPPSIPCPPP PSASFLSTEC
     VCITGVKCTT NLMPAEKIKS SMTQLSTTTV CKTDPQREPK GILRHVKNLA ELEKSVANMY
     SQIEKNYLRT NVSELQTMCP SEVTNMEITS EQNKGSLNNI VEGTEKQSHS QSTSL
//