ID   E7EME3_HUMAN            Unreviewed;       345 AA.
AC   E7EME3;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-JAN-2019, entry version 49.
DE   SubName: Full=C-type mannose receptor 2 {ECO:0000313|Ensembl:ENSP00000400445};
GN   Name=MRC2 {ECO:0000313|Ensembl:ENSP00000400445};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000400445, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000400445, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000400445}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
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DR   EMBL; AC080038; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E7EME3; -.
DR   EPD; E7EME3; -.
DR   jPOST; E7EME3; -.
DR   MaxQB; E7EME3; -.
DR   PeptideAtlas; E7EME3; -.
DR   PRIDE; E7EME3; -.
DR   Ensembl; ENST00000446119; ENSP00000400445; ENSG00000011028.
DR   UCSC; uc002jaf.5; human.
DR   EuPathDB; HostDB:ENSG00000011028.13; -.
DR   HGNC; HGNC:16875; MRC2.
DR   OpenTargets; ENSG00000011028; -.
DR   GeneTree; ENSGT00940000154008; -.
DR   ChiTaRS; MRC2; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000011028; Expressed in 239 organ(s), highest expression level in tendon of biceps brachii.
DR   ExpressionAtlas; E7EME3; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.100.10; -; 2.
DR   InterPro; IPR001304; C-type_lectin-like.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   Pfam; PF00059; Lectin_C; 1.
DR   SMART; SM00034; CLECT; 1.
DR   SUPFAM; SSF56436; SSF56436; 2.
DR   PROSITE; PS50041; C_TYPE_LECTIN_2; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:E7EME3,
KW   ECO:0000213|MaxQB:E7EME3, ECO:0000213|PeptideAtlas:E7EME3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    345       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003218956.
FT   TRANSMEM    279    302       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       62    104       C-type lectin.
FT                                {ECO:0000259|PROSITE:PS50041}.
FT   DOMAIN      139    250       C-type lectin.
FT                                {ECO:0000259|PROSITE:PS50041}.
SQ   SEQUENCE   345 AA;  37620 MW;  7E81EE97F36C45CA CRC64;
     MPTGHLGSPL ALALLPVATN RPAVQWSCTA PQPTSLAAGT IGAARRRPMA SSARRARGSR
     RYSWVSEEPL NYVGWQDGEP QQPGGCTYVD VDGAWRTTSC DTKLQGAVCG VSSGPPPPRR
     ISYHGSCPQG LADSAWIPFR EHCYSFHMEL LLGHKEARQR CQRAGGAVLS ILDEMENVFV
     WEHLQSYEGQ SRGAWLGMNF NPKGGTLVWQ DNTAVNYSNW GPPGLGPSML SHNSCYWIQS
     NSGLWRPGAC TNITMGVVCK LPRAEQSSFS PSALPENPAA LVVVLMAVLL LLALLTAALI
     LYRRRQSIER GAFEGARYSR SSSSPTEATE KNILVSDMEM NEQQE
//