ID E7EM97_HUMAN Unreviewed; 329 AA. AC E7EM97; DT 08-MAR-2011, integrated into UniProtKB/TrEMBL. DT 08-MAR-2011, sequence version 1. DT 05-DEC-2018, entry version 61. DE SubName: Full=Protocadherin-15 {ECO:0000313|Ensembl:ENSP00000412531}; GN Name=PCDH15 {ECO:0000313|Ensembl:ENSP00000412531}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000412531, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000412531, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164054; DOI=10.1038/nature02462; RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., RA Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., RA Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., RA Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., RA Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., RA Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., RA Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., RA Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., RA Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., RA Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., RA Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., RA Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., RA Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., RA Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., RA Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., RA Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., RA Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T., RA Doucette-Stamm L., Beck S., Smith D.R., Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 10."; RL Nature 429:375-381(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000412531} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC013737; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC016817; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC024073; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC027671; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL353784; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL360214; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL365496; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL391356; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF455239; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; E7EM97; -. DR PeptideAtlas; E7EM97; -. DR PRIDE; E7EM97; -. DR Ensembl; ENST00000414367; ENSP00000412531; ENSG00000150275. DR UCSC; uc057tig.1; human. DR EuPathDB; HostDB:ENSG00000150275.17; -. DR HGNC; HGNC:14674; PCDH15. DR OpenTargets; ENSG00000150275; -. DR eggNOG; KOG3594; Eukaryota. DR eggNOG; ENOG410XQHI; LUCA. DR GeneTree; ENSGT00940000156675; -. DR ChiTaRS; PCDH15; human. DR Proteomes; UP000005640; Chromosome 10. DR Bgee; ENSG00000150275; Expressed in 67 organ(s), highest expression level in corpus callosum. DR ExpressionAtlas; E7EM97; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:InterPro. DR GO; GO:0032420; C:stereocilium; IEA:InterPro. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro. DR GO; GO:0048839; P:inner ear development; IEA:InterPro. DR GO; GO:0007605; P:sensory perception of sound; IEA:InterPro. DR InterPro; IPR002126; Cadherin-like_dom. DR InterPro; IPR015919; Cadherin-like_sf. DR InterPro; IPR020894; Cadherin_CS. DR InterPro; IPR030718; Protocadherin-15. DR PANTHER; PTHR24028:SF11; PTHR24028:SF11; 2. DR Pfam; PF00028; Cadherin; 1. DR PRINTS; PR00205; CADHERIN. DR SMART; SM00112; CA; 2. DR SUPFAM; SSF49313; SSF49313; 1. DR PROSITE; PS00232; CADHERIN_1; 1. PE 4: Predicted; KW Calcium {ECO:0000256|SAAS:SAAS00020193}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAAS:SAAS00616217}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|SAAS:SAAS00436611}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00616217}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00616217}. FT SIGNAL 1 26 {ECO:0000256|SAM:SignalP}. FT CHAIN 27 329 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003218954. FT DOMAIN 64 145 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 174 263 CA. {ECO:0000259|SMART:SM00112}. SQ SEQUENCE 329 AA; 36928 MW; 1DBD05ACA132A4F0 CRC64; MFRQFYLWTC LASGIILGSL FEICLGQYDD DCKLARGGPP ATIVAIDEES RNGTILVDNM LIKGTAGGPD PTIELSLKDN VDYWVLMDPV KQMLFLNSTG RVLDRDPPMN IHSIVVQVQC INKKVGTIIY HEVRIVVRDR NDNSPTFKHE SYYATVNELT PVGTTIFTGF SGDNGATDID DGPNGQIEYV IQYNPDDPTS NDTFEIPLML TGNIVLRKRL NYEDKTRYFV IIQANDRAQN LNERRTTTTT LTVDVLDGDD LGPMFLPCVL VPNTRDCRPL TYQAAIPELR TPDLGSLCSG TNSWCQGRSG VHWSSPAWRC LFPRRLHQM //