ID   E7EM83_HUMAN            Unreviewed;       977 AA.
AC   E7EM83;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-JAN-2019, entry version 64.
DE   SubName: Full=Receptor-type tyrosine-protein phosphatase N2 {ECO:0000313|Ensembl:ENSP00000387114};
GN   Name=PTPRN2 {ECO:0000313|Ensembl:ENSP00000387114};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000387114, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000387114, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000213|PubMed:19608861}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19608861; DOI=10.1126/science.1175371;
RA   Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M.,
RA   Walther T.C., Olsen J.V., Mann M.;
RT   "Lysine acetylation targets protein complexes and co-regulates major
RT   cellular functions.";
RL   Science 325:834-840(2009).
RN   [3] {ECO:0000313|Ensembl:ENSP00000387114}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC005481; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC006003; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC006372; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC011899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458646; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF510998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF510999; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001295196.1; NM_001308267.1.
DR   UniGene; Hs.490789; -.
DR   ProteinModelPortal; E7EM83; -.
DR   jPOST; E7EM83; -.
DR   PeptideAtlas; E7EM83; -.
DR   PRIDE; E7EM83; -.
DR   Ensembl; ENST00000409483; ENSP00000387114; ENSG00000155093.
DR   GeneID; 5799; -.
DR   UCSC; uc003wnr.4; human.
DR   CTD; 5799; -.
DR   EuPathDB; HostDB:ENSG00000155093.17; -.
DR   HGNC; HGNC:9677; PTPRN2.
DR   OpenTargets; ENSG00000155093; -.
DR   eggNOG; KOG0793; Eukaryota.
DR   eggNOG; COG5599; LUCA.
DR   GeneTree; ENSGT00940000154095; -.
DR   OrthoDB; 411281at2759; -.
DR   ChiTaRS; PTPRN2; human.
DR   GenomeRNAi; 5799; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000155093; Expressed in 210 organ(s), highest expression level in caudate nucleus.
DR   ExpressionAtlas; E7EM83; baseline and differential.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR   Gene3D; 3.30.70.2470; -; 1.
DR   Gene3D; 3.90.190.10; -; 1.
DR   InterPro; IPR033522; IA-2/IA-2_beta.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000242; PTPase_domain.
DR   InterPro; IPR021613; Receptor_IA-2_dom.
DR   InterPro; IPR038112; Receptor_IA-2_ectodomain_sf.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR000387; TYR_PHOSPHATASE_dom.
DR   PANTHER; PTHR19134:SF266; PTHR19134:SF266; 1.
DR   Pfam; PF11548; Receptor_IA-2; 1.
DR   Pfam; PF00102; Y_phosphatase; 1.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM00194; PTPc; 1.
DR   SMART; SM00404; PTPc_motif; 1.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00160};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:E7EM83};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    977       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003217458.
FT   DOMAIN      707    967       Tyrosine-protein phosphatase.
FT                                {ECO:0000259|PROSITE:PS50055}.
FT   DOMAIN      886    958       TYR_PHOSPHATASE_2.
FT                                {ECO:0000259|PROSITE:PS50056}.
FT   ACT_SITE    907    907       Phosphocysteine intermediate.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00160}.
SQ   SEQUENCE   977 AA;  106989 MW;  D3297D96062D85F1 CRC64;
     MGPPLPLLLL LLLLLPPRVL PAAPSSVPRG RQLPGRLGCL LEEGLCGASE ACVNGFTWQD
     DYTQYVMDQE LADLPKTYLR RPEASSPARP SKHSVGSERR YSREGGAALA NALRRHLPFL
     EALSQAPASD VLARTHTAQD RPPAEGDDRF SESILTYVAH TSALTYPPGS RTQLREDLLP
     RTLGQLQPDE LSPKVDSGVD RHHLMAALSA YAAQRPPAPP GEGSLEPQYL LRAPSRMPRP
     LLAPAAPQKW PSPLGDSEDP SSTGDGARIH TLLKDLQRQP AEVRGLSGLE LDGMAELMAG
     LMQGVDHGVA RGSPGRAALG ESGEQADGPK ATLRGDSFPD DGVQDDDDRL YQEVHRLSAT
     LGGLLQDHGS RLLPGALPFA RPLDMERKKS EHPESSLSSE EETAGVENVK SQTYSKDLLG
     QQPHSEPGAA AFGELQNQMP GPSKEEQSLP AGAQEALSDG LQLEVQPSEE EARGYIVTDR
     DPLRPEEGRR LVEDVARLLQ VPSSAFADVE VLGPAVTFKV SANVQNVTTE DVEKATVDNK
     DKLEETSGLK ILQTGVGSKS KLKFLPPQAE QEDSTKFIAL TLVSLACILG VLLASGLIYC
     LRHSSQHRLK EKLSGLGGDP GADATAAYQE LCRQRMATRP PDRPEGPHTS RISSVSSQFS
     DGPIPSPSAR SSASSWSEEP VQSNMDISTG HMILSYMEDH LKNKNRLEKE WEALCAYQAE
     PNSSFVAQRE ENVPKNRSLA VLTYDHSRVL LKAENSHSHS DYINASPIMD HDPRNPAYIA
     TQGPLPATVA DFWQMVWESG CVVIVMLTPL AENGVRQCYH YWPDEGSNLY HIYEVNLVSE
     HIWCEDFLVR SFYLKNLQTN ETRTVTQFHF LSWYDRGVPS SSRSLLDFRR KVNKCYRGRS
     CPIIVHCSDG AGRSGTYVLI DMVLNKMAKG AKEIDIAATL EHLRDQRPGM VQTKEQFEFA
     LTAVAEEVNA ILKALPQ
//