ID   E7EM75_HUMAN            Unreviewed;      1606 AA.
AC   E7EM75;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-JAN-2019, entry version 52.
DE   SubName: Full=Thrombospondin type-1 domain-containing protein 7B {ECO:0000313|Ensembl:ENSP00000387145};
GN   Name=THSD7B {ECO:0000313|Ensembl:ENSP00000387145};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000387145, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000387145, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000387145}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC010100; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC010873; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC011231; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC012000; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC016679; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC017082; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC019067; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456714; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001303278.1; NM_001316349.1.
DR   UniGene; Hs.68533; -.
DR   ProteinModelPortal; E7EM75; -.
DR   jPOST; E7EM75; -.
DR   PRIDE; E7EM75; -.
DR   Ensembl; ENST00000409968; ENSP00000387145; ENSG00000144229.
DR   GeneID; 80731; -.
DR   KEGG; hsa:80731; -.
DR   UCSC; uc061ock.1; human.
DR   CTD; 80731; -.
DR   EuPathDB; HostDB:ENSG00000144229.11; -.
DR   HGNC; HGNC:29348; THSD7B.
DR   OpenTargets; ENSG00000144229; -.
DR   eggNOG; KOG3538; Eukaryota.
DR   eggNOG; ENOG410XR0P; LUCA.
DR   GeneTree; ENSGT00940000159262; -.
DR   OrthoDB; 20284at2759; -.
DR   ChiTaRS; THSD7B; human.
DR   GenomeRNAi; 80731; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000144229; Expressed in 108 organ(s), highest expression level in pigmented layer of retina.
DR   ExpressionAtlas; E7EM75; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.20.100.10; -; 10.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   Pfam; PF00090; TSP_1; 8.
DR   SMART; SM00209; TSP1; 16.
DR   SUPFAM; SSF82895; SSF82895; 12.
DR   PROSITE; PS50092; TSP1; 13.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     36       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        37   1606       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003217302.
FT   TRANSMEM   1556   1580       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   1606 AA;  179199 MW;  0947780C9CAD0B8C CRC64;
     MFPKSNLTVT CWVWRSMRKL FLLLSLLLSH AAHLEGKKDN QFIWKPGPWG RCTGDCGPGG
     VQSRAVWCFH VDGWTSHLSN CGESNRPPKE RSCFRVCDWH SDLFQWEVSD WHHCVLVPYA
     RGEVKPRTAE CVTAQHGLQH RMVRCIQKLN RTVVANEICE HFALQPPTEQ ACLIPCPRDC
     VVSEFLPWSN CSKGCGKKLQ HRTRAVIAPP LFGGLQCPNL TESRACDAPI SCPLGEEEYT
     FSLKVGPWSK CRLPHLKEIN PSGRTVLDFN SDSNERVTFK HQSYKAHHHS KSWAIEIGYQ
     TRQVSCTRSD GQNAMLSLCL QDSFPLTVQS CIMPKDCETS QWSSWSPCSK TCRSGSLLPG
     FRSRSRNVKH MAIGGGKECP ELLEKEACIV EGELLQQCPR YSWRTSEWKE CQVSLLLEQQ
     DPHWHVTGPV CGGGIQTREV YCAQSVPAAA ALRAKEVSRP VEKALCVGPA PLPSQLCNIP
     CSTDCIVSSW SAWGLCIHEN CHDPQGKKGF RTRQRHVLME STGPAGHCPH LVESVPCEDP
     MCYRWLASEG ICFPDHGKCG LGHRILKAVC QNDRGEDVSG SLCPVPPPPE RKSCEIPCRM
     DCVLSEWTEW SSCSQSCSNK NSDGKQTRSR TILALAGEGG KPCPPSQALQ EHRLCNDHSC
     MQLHWETSPW GPCSEDTLVT ALNATIGWNG EATCGVGIQT RRVFCVKSHV GQVMTKRCPD
     STRPETVRPC FLPCKKDCIV TAFSEWTPCP RMCQAGNATV KQSRYRIIIQ EAANGGQECP
     DTLYEERECE DVSLCPVYRW KPQKWSPCIL VPESVWQGIT GSSEACGKGL QTRAVSCISD
     DNRSAEMMEC LKQTNGMPLL VQECTVPCRE DCTFTAWSKF TPCSTNCEAT KSRRRQLTGK
     SRKKEKCQDS DLYPLVETEL CPCDEFISQP YGNWSDCILP EGRREPHRGL RVQADSKECG
     EGLRFRAVAC SDKNGRPVDP SFCSSSGYIQ EKCVIPCPFD CKLSDWSSWG SCSSSCGIGV
     RIRSKWLKEK PYNGGRPCPK LDLKNQVHEA VPCYSECNQY SWVVEHWSSC KINNELRSLR
     CGGGTQSRKI RCVNTADGEG GAVDSNLCNQ DEIPPETQSC SLMCPNECVM SEWGLWSKCP
     QSCDPHTMQR RTRHLLRPSL NSRTCAEDSQ VQPCLLNENC FQFQYNLTEW STCQLSENAP
     CGQGVRTRLL SCVCSDGKPV SMDQCEQHNL EKPQRMSIPC LVECVVNCQL SGWTAWTECS
     QTCGHGGRMS RTRFIIMPTQ GEGRPCPTEL TQEKTCPVTP CYSWVLGNWS ACKLEGGDCG
     EGVQIRSLSC MVHSGSISHA AGRVEDALCG EMPFQDSILK QLCSVPCPGD CHLTEWSEWS
     TCELTCIDGR SFETVGRQSR SRTFIIQSFE NQDSCPQQVL ETRPCTGGKC YHYTWKASLW
     NNNERTVWCQ RSDGVNVTGG CSPQARPAAI RQCIPACRKP FSYCTQGGVC GCEKGYTEIM
     KSNGFLDYCM KVPGSEDKKA DVKNLSGKNR PVNSKIHDIF KGWSLQPLDP DGRVKIWVYG
     VSGGAFLIMI FLIFTSYLVC KKPKPHQSTP PQQKPLTLAY DGDLDM
//