ID   E7EM53_HUMAN            Unreviewed;      1886 AA.
AC   E7EM53;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 2.
DT   16-JAN-2019, entry version 62.
DE   SubName: Full=Protocadherin-15 {ECO:0000313|Ensembl:ENSP00000412628};
GN   Name=PCDH15 {ECO:0000313|Ensembl:ENSP00000412628};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000412628, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000412628, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA   Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA   Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA   Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA   Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA   Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA   Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA   Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA   Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA   Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA   Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA   Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA   Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA   Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA   Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA   Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T.,
RA   Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000412628}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC013737; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC016817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC024073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC027671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL353784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL360214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL365496; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL391356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001136237.1; NM_001142765.1.
DR   UniGene; Hs.280209; -.
DR   ProteinModelPortal; E7EM53; -.
DR   MaxQB; E7EM53; -.
DR   PRIDE; E7EM53; -.
DR   Ensembl; ENST00000437009; ENSP00000412628; ENSG00000150275.
DR   GeneID; 65217; -.
DR   UCSC; uc057tir.1; human.
DR   CTD; 65217; -.
DR   EuPathDB; HostDB:ENSG00000150275.17; -.
DR   HGNC; HGNC:14674; PCDH15.
DR   OpenTargets; ENSG00000150275; -.
DR   GeneTree; ENSGT00940000156675; -.
DR   OrthoDB; 21247at2759; -.
DR   ChiTaRS; PCDH15; human.
DR   GenomeRNAi; 65217; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; ENSG00000150275; Expressed in 67 organ(s), highest expression level in corpus callosum.
DR   ExpressionAtlas; E7EM53; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0032420; C:stereocilium; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   GO; GO:0048839; P:inner ear development; IEA:InterPro.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:InterPro.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR030718; Protocadherin-15.
DR   PANTHER; PTHR24028:SF11; PTHR24028:SF11; 4.
DR   Pfam; PF00028; Cadherin; 7.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 10.
DR   SUPFAM; SSF49313; SSF49313; 10.
DR   PROSITE; PS00232; CADHERIN_1; 3.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|SAAS:SAAS00020193};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00616217, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:E7EM53};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00436611};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00616217,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00616217,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     26       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        27   1886       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003219409.
FT   TRANSMEM   1304   1326       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       64    145       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      174    263       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      304    393       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      426    507       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      531    644       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      668    746       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      770    853       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      877    963       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      984   1071       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN     1095   1179       CA. {ECO:0000259|SMART:SM00112}.
SQ   SEQUENCE   1886 AA;  208360 MW;  352D1B8FEBE0DDC1 CRC64;
     MFRQFYLWTC LASGIILGSL FEICLGQYDD DCKLARGGPP ATIVAIDEES RNGTILVDNM
     LIKGTAGGPD PTIELSLKDN VDYWVLMDPV KQMLFLNSTG RVLDRDPPMN IHSIVVQVQC
     INKKVGTIIY HEVRIVVRDR NDNSPTFKHE SYYATVNELT PVGTTIFTGF SGDNGATDID
     DGPNGQIEYV IQYNPDDPTS NDTFEIPLML TGNIVLRKRL NYEDKTRYFV IIQANDRAQN
     LNERRTTTTT LTVDVLDGDD LGPMFLPCVL VPNTRDCRPL TYQAAIPELR TPEELNPIIV
     TPPIQAIDQD RNIQPPSDRP GILYSILVGT PEDYPRFFHM HPRTAELSLL EPVNRDFHQK
     FDLVIKAEQD NGHPLPAFAG LHIEILDENN QSPYFTMPSY QGYILESAPV GATISDSLNL
     TSPLRIVALD KDIEDTKDPE LHLFLNDYTS VFTVTQTGIT RYLTLLQPVD REEQQTYTFS
     ITAFDGVQES EPVIVNIQVM DANDNTPTFP EISYDVYVYT DMRPGDSVIQ LTAVDADEGS
     NGEITYEILV GAQGDFIINK TTGLITIAPG VEMIVGRTYA LTVQAADNAP PAERSTGILT
     LGKALDREST DRYILIITAS DGRPDGTSTA TVNIVVTDVN DNAPVFDPYL PRNLSVVEEE
     ANAFVGQVKA TDPDAGINGQ VHYSLGNFNN LFRITSNGSI YTAVKLNREV RDYYELVVVA
     TDGAVHPRHS TLTLAIKVLD IDDNSPVFTN STYTVLVEEN LPAGTTILQI EAKDVDLGAN
     VSYRIRSPEV KHFFALHPFT GELSLLRSLD YEAFPDQEAS ITFLVEAFDI YGTMPPGIAT
     VTVIVKDMND YPPVFSKRIY KGMVAPDAVK GTPITTVYAE DADPPGLPAS RVRYRVDDVQ
     FPYPASIFEV EEDSGRVITR VNLNEEPTTI FKLVVVAFDD GEPVMSSSAT VKILVLHPGE
     IPRFTQEEYR PPPVSELATK GTMVGVISAA AINQSIVYSI VSGNEEDTFG INNITGVIYV
     NGPLDYETRT SYVLRVQADS LEVVLANLRV PSKSNTAKVY IEIQDENNHP PVFQKKFYIG
     GVSEDARMFT SVLRVKATDK DTGNYSVMAY RLIIPPIKEG KEGFVVETYT GLIKTAMLFH
     NMRRSYFKFQ VIATDDYGKG LSGKADVLVS VVNQLDMQVI VSNVPPTLVE KKIEDLTEIL
     DRYVQEQIPG AKVVVESIGA RRHGDAFSLE DYTKCDLTVY AIDPQTNRAI DRNELFKFLD
     GKLLDINKDF QPYYGEGGRI LEIRTPEAVT SIKKRGESLG YTEGALLALA FIIILCCIPA
     ILVVLVSYRQ FKVRQAECTK TARIQAALPA AKPAVPAPAP VAAPPPPPPP PPGAHLYEEL
     GDSSMHNLFL LYHFQQSRGN NSVSEDRKHQ QVVMPFSSNT IEAHKSAHVD GSLKSNKLKS
     ARKFTFLSDE DDLSAHNPLY KENISQVSTN SDISQRTDFV DPFSPKIQAK SKSLRGPREK
     IQRLWSQSVS LPRRLMRKVP NRPEIIDLQQ WQGTRQKAEN ENTGICTNKR GSSNPLLTTE
     EANLTEKEEI RQGETLMIEG TEQLKSLSSD SSFCFPRPHF SFSTLPTVSR TVELKSEPNV
     ISSPAECSLE LSPSRPCVLH SSLSRRETPI CMLPIETERN IFENFAHPPN ISPSACPLPP
     PPPISPPSPP PAPAPLAPPP DISPFSLFCP PPSPPSIPLP LPPPTFFPLS VSTSGPPTPP
     LLPPFPTPLP PPPPSIPCPP PPSASFLSTE CVCITGVKCT TNLMPAEKIK SSMTQLSTTT
     VCKTDPQREP KGILRHVKNL AELEKSVANM YSQIEKNYLR TNVSELQTMC PSEVTNMEIT
     SEQNKGSLNN IVEGTEKQSH SQSTSL
//