ID   E5RK96_HUMAN            Unreviewed;       115 AA.
AC   E5RK96;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   05-DEC-2018, entry version 54.
DE   SubName: Full=Disintegrin and metalloproteinase domain-containing protein 18 {ECO:0000313|Ensembl:ENSP00000428083};
GN   Name=ADAM18 {ECO:0000313|Ensembl:ENSP00000428083};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000428083, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000428083, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000428083}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSP00000484966}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
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DR   EMBL; AC109633; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC136365; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC244257; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC245062; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458743; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PRIDE; E5RK96; -.
DR   Ensembl; ENST00000520087; ENSP00000428083; ENSG00000168619.
DR   Ensembl; ENST00000614391; ENSP00000484966; ENSG00000278548.
DR   UCSC; uc064mfp.1; human.
DR   EuPathDB; HostDB:ENSG00000168619.15; -.
DR   HGNC; HGNC:196; ADAM18.
DR   OpenTargets; ENSG00000168619; -.
DR   eggNOG; KOG3607; Eukaryota.
DR   eggNOG; ENOG410XX2M; LUCA.
DR   GeneTree; ENSGT00940000162281; -.
DR   ChiTaRS; ADAM18; human.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000168619; Expressed in 29 organ(s), highest expression level in right testis.
DR   ExpressionAtlas; E5RK96; baseline and differential.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     16       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        17    115       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014570870.
FT   DOMAIN       28    115       Pep_M12B_propep.
FT                                {ECO:0000259|Pfam:PF01562}.
SQ   SEQUENCE   115 AA;  13089 MW;  37B0E2A76C163C5B CRC64;
     MFLLLALLTE LGRLQAHEGS EGIFLHVTVP RKIKSNDSEV SERKMIYIIT IDGQPYTLHL
     GKQSFLPQNF LVYTYNETGS LHSVSPYFMM HCHYQGYAAE FPNSFVTLSI CSGLR
//