ID   E5RK60_HUMAN            Unreviewed;       168 AA.
AC   E5RK60;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 2.
DT   05-DEC-2018, entry version 48.
DE   SubName: Full=Gamma-aminobutyric acid receptor subunit alpha-1 {ECO:0000313|Ensembl:ENSP00000430435};
DE   Flags: Fragment;
GN   Name=GABRA1 {ECO:0000313|Ensembl:ENSP00000430435};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000430435, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000430435, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000430435}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC021079; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC108130; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PeptideAtlas; E5RK60; -.
DR   PRIDE; E5RK60; -.
DR   Ensembl; ENST00000519621; ENSP00000430435; ENSG00000022355.
DR   UCSC; uc063jhr.1; human.
DR   EuPathDB; HostDB:ENSG00000022355.15; -.
DR   HGNC; HGNC:4075; GABRA1.
DR   OpenTargets; ENSG00000022355; -.
DR   eggNOG; KOG3642; Eukaryota.
DR   eggNOG; ENOG410XNQG; LUCA.
DR   GeneTree; ENSGT00940000159136; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000022355; Expressed in 84 organ(s), highest expression level in dorsolateral prefrontal cortex.
DR   ExpressionAtlas; E5RK60; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
DR   GO; GO:0004890; F:GABA-A receptor activity; IEA:InterPro.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR001390; GABAAa_rcpt.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   PRINTS; PR01079; GABAARALPHA.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF63712; SSF63712; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:E5RK60};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     27       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        28    168       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5006723863.
FT   DOMAIN       43    168       Neur_chan_LBD.
FT                                {ECO:0000259|Pfam:PF02931}.
FT   NON_TER     168    168       {ECO:0000313|Ensembl:ENSP00000430435}.
SQ   SEQUENCE   168 AA;  19437 MW;  72AA2FB6C4883D38 CRC64;
     MRKSPGLSDC LWAWILLLST LTGRSYGQPS LQDELKDNTT VFTRILDRLL DGYDNRLRPG
     LGERVTEVKT DIFVTSFGPV SDHDMEYTID VFFRQSWKDE RLKFKGPMTV LRLNNLMASK
     IWTPDTFFHN GKKSVAHNMT MPNKLLRITE DGTLLYTMRL TVRAECPM
//