ID   E5RK25_HUMAN            Unreviewed;       160 AA.
AC   E5RK25;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   16-JAN-2019, entry version 56.
DE   RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
DE   Flags: Fragment;
GN   Name=ITGB2 {ECO:0000313|Ensembl:ENSP00000428979};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000428979, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000428979, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10830953; DOI=10.1038/35012518;
RG   Chromosome 21 mapping and sequencing consortium;
RA   Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T.,
RA   Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y.,
RA   Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K.,
RA   Polley A., Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D.,
RA   Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W.,
RA   Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S.,
RA   Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E.,
RA   Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P.,
RA   Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H.,
RA   Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E.,
RA   Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F.,
RA   Lehrach H., Reinhardt R., Yaspo M.-L.;
RT   "The DNA sequence of human chromosome 21.";
RL   Nature 405:311-319(2000).
RN   [2] {ECO:0000313|Ensembl:ENSP00000428979}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU000633};
CC       Single-pass type I membrane protein
CC       {ECO:0000256|RuleBase:RU000633}.
CC   -!- SIMILARITY: Belongs to the integrin beta chain family.
CC       {ECO:0000256|RuleBase:RU000633}.
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DR   EMBL; AL773603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL844907; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL844908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   jPOST; E5RK25; -.
DR   MaxQB; E5RK25; -.
DR   PeptideAtlas; E5RK25; -.
DR   PRIDE; E5RK25; -.
DR   Ensembl; ENST00000522931; ENSP00000428979; ENSG00000160255.
DR   UCSC; uc062auf.1; human.
DR   EuPathDB; HostDB:ENSG00000160255.16; -.
DR   HGNC; HGNC:6155; ITGB2.
DR   OpenTargets; ENSG00000160255; -.
DR   eggNOG; KOG1226; Eukaryota.
DR   eggNOG; ENOG410XP60; LUCA.
DR   GeneTree; ENSGT00940000157111; -.
DR   SignaLink; E5RK25; -.
DR   ChiTaRS; ITGB2; human.
DR   Proteomes; UP000005640; Chromosome 21.
DR   Bgee; ENSG00000160255; Expressed in 187 organ(s), highest expression level in blood.
DR   ExpressionAtlas; E5RK25; baseline and differential.
DR   GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR033760; Integrin_beta_N.
DR   InterPro; IPR015812; Integrin_bsu.
DR   InterPro; IPR015439; Integrin_bsu-2.
DR   InterPro; IPR002369; Integrin_bsu_VWA.
DR   InterPro; IPR016201; PSI.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10082; PTHR10082; 1.
DR   PANTHER; PTHR10082:SF15; PTHR10082:SF15; 1.
DR   Pfam; PF00362; Integrin_beta; 1.
DR   Pfam; PF17205; PSI_integrin; 1.
DR   PRINTS; PR01186; INTEGRINB.
DR   SMART; SM00187; INB; 1.
DR   SMART; SM00423; PSI; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
PE   1: Evidence at protein level;
KW   Cell adhesion {ECO:0000256|RuleBase:RU000633};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Integrin {ECO:0000256|RuleBase:RU000633};
KW   Membrane {ECO:0000256|RuleBase:RU000633};
KW   Proteomics identification {ECO:0000213|EPD:E5RK25,
KW   ECO:0000213|MaxQB:E5RK25, ECO:0000213|PeptideAtlas:E5RK25};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|RuleBase:RU000633}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    160       Integrin beta. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003196838.
FT   DOMAIN       24     74       PSI. {ECO:0000259|SMART:SM00423}.
FT   DOMAIN       32    159       INB. {ECO:0000259|SMART:SM00187}.
FT   NON_TER     160    160       {ECO:0000313|Ensembl:ENSP00000428979}.
SQ   SEQUENCE   160 AA;  17644 MW;  47D31BD3B00E5629 CRC64;
     MLGLRPPLLA LVGLLSLGCV LSQECTKFKV SSCRECIESG PGCTWCQKLN FTGPGDPDSI
     RCDTRPQLLM RGCAADDIMD PTSLAETQED HNGGQKQLSP QKVTLYLRPG QAAAFNVTFR
     RAKGYPIDLY YLMDLSYSML DDLRNVKKLG GDLLRALNEI
//