ID   E5RJP4_HUMAN            Unreviewed;       216 AA.
AC   E5RJP4;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   16-JAN-2019, entry version 58.
DE   SubName: Full=Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 {ECO:0000313|Ensembl:ENSP00000431125};
DE   Flags: Fragment;
GN   Name=GFPT2 {ECO:0000313|Ensembl:ENSP00000431125};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000431125, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000431125, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000213|PubMed:18669648}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [3] {ECO:0000213|PubMed:21406692}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA   Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
RA   Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
RA   Blagoev B.;
RT   "System-wide temporal characterization of the proteome and
RT   phosphoproteome of human embryonic stem cell differentiation.";
RL   Sci. Signal. 4:rs3-RS3(2011).
RN   [4] {ECO:0000313|Ensembl:ENSP00000431125}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [5] {ECO:0000213|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
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DR   EMBL; AC008610; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E5RJP4; -.
DR   jPOST; E5RJP4; -.
DR   MaxQB; E5RJP4; -.
DR   PeptideAtlas; E5RJP4; -.
DR   PRIDE; E5RJP4; -.
DR   Ensembl; ENST00000518906; ENSP00000431125; ENSG00000131459.
DR   UCSC; uc063ktp.1; human.
DR   EuPathDB; HostDB:ENSG00000131459.12; -.
DR   HGNC; HGNC:4242; GFPT2.
DR   OpenTargets; ENSG00000131459; -.
DR   eggNOG; KOG1268; Eukaryota.
DR   eggNOG; COG0449; LUCA.
DR   GeneTree; ENSGT00940000156413; -.
DR   ChiTaRS; GFPT2; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000131459; Expressed in 194 organ(s), highest expression level in layer of synovial tissue.
DR   ExpressionAtlas; E5RJP4; baseline and differential.
DR   InterPro; IPR017932; GATase_2_dom.
DR   InterPro; IPR029055; Ntn_hydrolases_N.
DR   Pfam; PF13537; GATase_7; 1.
DR   SUPFAM; SSF56235; SSF56235; 1.
DR   PROSITE; PS51278; GATASE_TYPE_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:E5RJP4,
KW   ECO:0000213|PeptideAtlas:E5RJP4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    216       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003196884.
FT   DOMAIN        1    190       Glutamine amidotransferase type-2.
FT                                {ECO:0000259|PROSITE:PS51278}.
FT   NON_TER     216    216       {ECO:0000313|Ensembl:ENSP00000431125}.
SQ   SEQUENCE   216 AA;  24414 MW;  6CB3C53B903B0B39 CRC64;
     MNLLLNSISL LTFLSEFVVI HNGIITNYKD LRKFLESKGY EFESETDTET IAKLIKYVFD
     NRETEDITFS TLVERVIQQL EGAFALVFKS VHYPGEAVAT RRGSPLLIGV RSKYKLSTEQ
     IPILYRTCTL ENVKNICKTR MKRLDSSACL HAVGDKAVEF FFASDASAII EHTNRVIFLE
     DDDIAAVADG KLSIHRVKRS ASDDPSRAIQ TLQMEL
//