ID   E5RJL2_HUMAN            Unreviewed;       151 AA.
AC   E5RJL2;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   16-JAN-2019, entry version 58.
DE   SubName: Full=Lysyl oxidase homolog 2 {ECO:0000313|Ensembl:ENSP00000430519};
DE   Flags: Fragment;
GN   Name=LOXL2 {ECO:0000313|Ensembl:ENSP00000430519};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000430519, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000430519, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000430519}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
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DR   EMBL; AC090197; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC104561; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E5RJL2; -.
DR   SMR; E5RJL2; -.
DR   jPOST; E5RJL2; -.
DR   MaxQB; E5RJL2; -.
DR   PeptideAtlas; E5RJL2; -.
DR   PRIDE; E5RJL2; -.
DR   Ensembl; ENST00000518083; ENSP00000430519; ENSG00000134013.
DR   UCSC; uc064lev.1; human.
DR   EuPathDB; HostDB:ENSG00000134013.15; -.
DR   HGNC; HGNC:6666; LOXL2.
DR   OpenTargets; ENSG00000134013; -.
DR   eggNOG; ENOG410IE2X; Eukaryota.
DR   eggNOG; ENOG410XSN1; LUCA.
DR   GeneTree; ENSGT00940000155874; -.
DR   ChiTaRS; LOXL2; human.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000134013; Expressed in 180 organ(s), highest expression level in smooth muscle tissue.
DR   ExpressionAtlas; E5RJL2; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR   Gene3D; 3.10.250.10; -; 1.
DR   InterPro; IPR001190; SRCR.
DR   InterPro; IPR017448; SRCR-like_dom.
DR   InterPro; IPR036772; SRCR-like_dom_sf.
DR   Pfam; PF00530; SRCR; 1.
DR   PRINTS; PR00258; SPERACTRCPTR.
DR   SMART; SM00202; SR; 1.
DR   SUPFAM; SSF56487; SSF56487; 1.
DR   PROSITE; PS50287; SRCR_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00196,
KW   ECO:0000256|SAAS:SAAS00873970};
KW   Proteomics identification {ECO:0000213|MaxQB:E5RJL2,
KW   ECO:0000213|PeptideAtlas:E5RJL2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    151       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003198623.
FT   DOMAIN       58    151       SRCR. {ECO:0000259|PROSITE:PS50287}.
FT   DISULFID     84    148       {ECO:0000256|PROSITE-ProRule:PRU00196}.
FT   DISULFID    128    138       {ECO:0000256|PROSITE-ProRule:PRU00196}.
FT   NON_TER     151    151       {ECO:0000313|Ensembl:ENSP00000430519}.
SQ   SEQUENCE   151 AA;  16770 MW;  0EBE41F0A7625B84 CRC64;
     MERPLCSHLC SCLAMLALLS PLSLAQYDSW PHYPEYFQQP APEYHQPQAP ANVAKIQLRL
     AGQKRKHSEG RVEVYYDGQW GTVCDDDFSI HAAHVVCREL GYVEAKSWTA SSSYGKGEGP
     IWLDNLHCTG NEATLAACTS NGWGVTDCKH T
//