ID E5RJD8_HUMAN Unreviewed; 119 AA. AC E5RJD8; DT 08-FEB-2011, integrated into UniProtKB/TrEMBL. DT 08-FEB-2011, sequence version 1. DT 16-JAN-2019, entry version 55. DE RecName: Full=Tubulin-specific chaperone A {ECO:0000256|RuleBase:RU364030}; GN Name=TBCA {ECO:0000313|Ensembl:ENSP00000429083}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000429083, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000429083, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15372022; DOI=10.1038/nature02919; RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., RA Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., RA Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., RA Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., RA Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., RA Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., RA Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., RA Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., RA Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., RA Richardson P., Lucas S.M., Myers R.M., Rubin E.M.; RT "The DNA sequence and comparative analysis of human chromosome 5."; RL Nature 431:268-274(2004). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000429083} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [4] {ECO:0000213|PubMed:22905912} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=22905912; DOI=10.1021/pr300539b; RA Rosenow A., Noben J.P., Jocken J., Kallendrusch S., RA Fischer-Posovszky P., Mariman E.C., Renes J.; RT "Resveratrol-induced changes of the human adipocyte secretion RT profile."; RL J. Proteome Res. 11:4733-4743(2012). CC -!- SUBUNIT: Supercomplex made of cofactors A to E. Cofactors A and D CC function by capturing and stabilizing tubulin in a quasi-native CC conformation. Cofactor E binds to the cofactor D-tubulin complex; CC interaction with cofactor C then causes the release of tubulin CC polypeptides that are committed to the native state. CC {ECO:0000256|RuleBase:RU364030}. CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton CC {ECO:0000256|RuleBase:RU364030}. CC -!- SIMILARITY: Belongs to the TBCA family. CC {ECO:0000256|RuleBase:RU364030}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC026717; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC035147; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC108482; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF510913; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; E5RJD8; -. DR EPD; E5RJD8; -. DR jPOST; E5RJD8; -. DR MaxQB; E5RJD8; -. DR PeptideAtlas; E5RJD8; -. DR PRIDE; E5RJD8; -. DR Ensembl; ENST00000517679; ENSP00000429083; ENSG00000171530. DR UCSC; uc063euj.1; human. DR EuPathDB; HostDB:ENSG00000171530.13; -. DR HGNC; HGNC:11579; TBCA. DR OpenTargets; ENSG00000171530; -. DR eggNOG; KOG3470; Eukaryota. DR eggNOG; ENOG4111Y9A; LUCA. DR GeneTree; ENSGT00390000009710; -. DR ChiTaRS; TBCA; human. DR Proteomes; UP000005640; Chromosome 5. DR Bgee; ENSG00000171530; Expressed in 113 organ(s), highest expression level in left adrenal gland. DR ExpressionAtlas; E5RJD8; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW. DR GO; GO:0015630; C:microtubule cytoskeleton; IDA:HPA. DR GO; GO:0005730; C:nucleolus; IDA:HPA. DR GO; GO:0048487; F:beta-tubulin binding; IEA:InterPro. DR GO; GO:0007023; P:post-chaperonin tubulin folding pathway; IEA:UniProtKB-UniRule. DR GO; GO:0007021; P:tubulin complex assembly; IEA:UniProtKB-UniRule. DR InterPro; IPR004226; TBCA. DR InterPro; IPR036126; TBCA_sf. DR PANTHER; PTHR21500; PTHR21500; 1. DR Pfam; PF02970; TBCA; 1. DR ProDom; PD010430; CofA_tubulin_bd; 1. DR SUPFAM; SSF46988; SSF46988; 1. PE 1: Evidence at protein level; KW Chaperone {ECO:0000256|RuleBase:RU364030}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Cytoplasm {ECO:0000256|RuleBase:RU364030}; KW Cytoskeleton {ECO:0000256|RuleBase:RU364030}; KW Microtubule {ECO:0000256|RuleBase:RU364030}; KW Proteomics identification {ECO:0000213|EPD:E5RJD8, KW ECO:0000213|MaxQB:E5RJD8, ECO:0000213|PeptideAtlas:E5RJD8}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 119 Tubulin-specific chaperone A. FT {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003198029. FT COILED 27 54 {ECO:0000256|SAM:Coils}. FT COILED 82 102 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 119 AA; 14306 MW; B6F846451FA6F912 CRC64; MLTRTSWFHG FFSWFSSSIC WSTLSKFLRL VKEKVMYEKE AKQQEEKIEK MRAEDGENYD IKKQAEILQE SRMMIPDCQR RLEAAYLDLQ RILENEKDLE EAEEYKEARL VLDSVKLEA //