ID   E5RJ72_HUMAN            Unreviewed;        92 AA.
AC   E5RJ72;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   07-NOV-2018, entry version 44.
DE   SubName: Full=Proenkephalin-A {ECO:0000313|Ensembl:ENSP00000430592};
GN   Name=PENK {ECO:0000313|Ensembl:ENSP00000430592};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000430592, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000430592, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000430592}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC023464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; E5RJ72; -.
DR   PeptideAtlas; E5RJ72; -.
DR   PRIDE; E5RJ72; -.
DR   Ensembl; ENST00000518770; ENSP00000430592; ENSG00000181195.
DR   UCSC; uc010lym.4; human.
DR   EuPathDB; HostDB:ENSG00000181195.10; -.
DR   HGNC; HGNC:8831; PENK.
DR   OpenTargets; ENSG00000181195; -.
DR   GeneTree; ENSGT00530000063761; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000181195; Expressed in 187 organ(s), highest expression level in caudate nucleus.
DR   ExpressionAtlas; E5RJ72; baseline and differential.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro.
DR   InterPro; IPR006024; Opioid_neupept.
DR   InterPro; IPR000703; Proenkphlin_A.
DR   PANTHER; PTHR11438; PTHR11438; 1.
DR   PANTHER; PTHR11438:SF3; PTHR11438:SF3; 1.
DR   PRINTS; PR01029; PENKAPRCRSR.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21     92       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003198422.
SQ   SEQUENCE   92 AA;  10256 MW;  2B55138FE2AAB758 CRC64;
     MARFLTLCTW LLLLGPGLLA TVRAECSQDC ATCSYRLVRP ADINFLVSVA RGECCAPCET
     EFPQQYADCL RPTARRVWRF APGRSRSGAS PW
//