ID   E5RJ09_HUMAN            Unreviewed;       197 AA.
AC   E5RJ09;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   16-JAN-2019, entry version 44.
DE   SubName: Full=Erlin-2 {ECO:0000313|Ensembl:ENSP00000429229};
DE   Flags: Fragment;
GN   Name=ERLIN2 {ECO:0000313|Ensembl:ENSP00000429229};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000429229, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000429229, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000429229}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [5] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
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DR   EMBL; AC138356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E5RJ09; -.
DR   jPOST; E5RJ09; -.
DR   MaxQB; E5RJ09; -.
DR   PeptideAtlas; E5RJ09; -.
DR   PRIDE; E5RJ09; -.
DR   Ensembl; ENST00000518526; ENSP00000429229; ENSG00000147475.
DR   UCSC; uc064lxr.1; human.
DR   EuPathDB; HostDB:ENSG00000147475.14; -.
DR   HGNC; HGNC:1356; ERLIN2.
DR   OpenTargets; ENSG00000147475; -.
DR   GeneTree; ENSGT00390000014666; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000147475; Expressed in 219 organ(s), highest expression level in choroid plexus epithelium.
DR   ExpressionAtlas; E5RJ09; baseline and differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IEA:InterPro.
DR   InterPro; IPR001107; Band_7.
DR   InterPro; IPR033294; Erlin1/2.
DR   PANTHER; PTHR15351; PTHR15351; 2.
DR   Pfam; PF01145; Band_7; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:E5RJ09,
KW   ECO:0000213|MaxQB:E5RJ09, ECO:0000213|PeptideAtlas:E5RJ09};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    197       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003198611.
FT   DOMAIN       48    164       PHB. {ECO:0000259|Pfam:PF01145}.
FT   NON_TER     197    197       {ECO:0000313|Ensembl:ENSP00000429229}.
SQ   SEQUENCE   197 AA;  22316 MW;  EB1DD48FA3EEDD55 CRC64;
     MAQLGAVVAV ASSFFCASLF SAVHKIEEGH IGVYYSGGVM IYFDRIEVVN FLVPNAVYDI
     VKNYTADYDK ALIFNKIHHE LNQFCSVHTL QEVYIELFDQ IDENLKLALQ QDLTSMAPGL
     VIQAVRVTKP NIPEAIRRNY ELMESEKTKL LIAAQKQKVV EKEAETERKK ALIEAEKVAQ
     VAEITYGQKV MEKETEK
//