ID   E5RIS2_HUMAN            Unreviewed;       272 AA.
AC   E5RIS2;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   05-DEC-2018, entry version 52.
DE   SubName: Full=Disintegrin and metalloproteinase domain-containing protein 19 {ECO:0000313|Ensembl:ENSP00000428376};
GN   Name=ADAM19 {ECO:0000313|Ensembl:ENSP00000428376};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000428376, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000428376, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000428376}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC008676; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC008694; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC106801; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E5RIS2; -.
DR   MaxQB; E5RIS2; -.
DR   PeptideAtlas; E5RIS2; -.
DR   PRIDE; E5RIS2; -.
DR   Ensembl; ENST00000517951; ENSP00000428376; ENSG00000135074.
DR   UCSC; uc063jdl.1; human.
DR   EuPathDB; HostDB:ENSG00000135074.15; -.
DR   HGNC; HGNC:197; ADAM19.
DR   OpenTargets; ENSG00000135074; -.
DR   eggNOG; KOG3607; Eukaryota.
DR   eggNOG; ENOG410XX2M; LUCA.
DR   GeneTree; ENSGT00940000159624; -.
DR   ChiTaRS; ADAM19; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000135074; Expressed in 209 organ(s), highest expression level in blood.
DR   ExpressionAtlas; E5RIS2; baseline and differential.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0017124; F:SH3 domain binding; IEA:InterPro.
DR   GO; GO:0006509; P:membrane protein ectodomain proteolysis; IEA:InterPro.
DR   InterPro; IPR033596; ADAM19.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   PANTHER; PTHR11905:SF19; PTHR11905:SF19; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF01421; Reprolysin; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:E5RIS2,
KW   ECO:0000213|PeptideAtlas:E5RIS2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    272       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003198417.
FT   DOMAIN       58    162       Pep_M12B_propep.
FT                                {ECO:0000259|Pfam:PF01562}.
FT   DOMAIN      210    247       Peptidase M12B.
FT                                {ECO:0000259|Pfam:PF01421}.
SQ   SEQUENCE   272 AA;  31058 MW;  C762ED57A609AC7C CRC64;
     MPGGAGAARL CLLAFALQPL RPRAAREPGW TRGSEEGSPK LQHELIIPQW KTSESPVREK
     HPLKAELRVM AEGRELILDL EKNEQLFAPS YTETHYTSSG NPQTTTRKLE DHCFYHGTVR
     ETELSSVTLS TCRGIRGLIT VSSNLSYVIE PLPDSKGQHL IYRSEHLKPP PGNCGFEHSK
     PTTRDWALQF TQQTKKRPRR MKREDLNSMK YVELYLVADY LEFQKNRRDQ DATKHKLIEI
     ANYVDKVRPV LPILEHPDCS RGLGSVDPRE HV
//