ID   E5RIP6_HUMAN            Unreviewed;        79 AA.
AC   E5RIP6;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   07-NOV-2018, entry version 41.
DE   SubName: Full=Proenkephalin-A {ECO:0000313|Ensembl:ENSP00000429326};
GN   Name=PENK {ECO:0000313|Ensembl:ENSP00000429326};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000429326, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000429326, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000429326}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC023464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E5RIP6; -.
DR   SMR; E5RIP6; -.
DR   PeptideAtlas; E5RIP6; -.
DR   PRIDE; E5RIP6; -.
DR   Ensembl; ENST00000523051; ENSP00000429326; ENSG00000181195.
DR   UCSC; uc064mzj.1; human.
DR   EuPathDB; HostDB:ENSG00000181195.10; -.
DR   HGNC; HGNC:8831; PENK.
DR   OpenTargets; ENSG00000181195; -.
DR   GeneTree; ENSGT00530000063761; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000181195; Expressed in 187 organ(s), highest expression level in caudate nucleus.
DR   ExpressionAtlas; E5RIP6; baseline and differential.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro.
DR   InterPro; IPR006024; Opioid_neupept.
DR   InterPro; IPR000703; Proenkphlin_A.
DR   PANTHER; PTHR11438; PTHR11438; 1.
DR   PANTHER; PTHR11438:SF3; PTHR11438:SF3; 1.
DR   Pfam; PF01160; Opiods_neuropep; 1.
DR   PRINTS; PR01029; PENKAPRCRSR.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21     79       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003198604.
SQ   SEQUENCE   79 AA;  8764 MW;  A7F5942D518CA237 CRC64;
     MARFLTLCTW LLLLGPGLLA TVRAECSQDC ATCSYRLVRP ADINFLDCGG GEEEGCSFQN
     FPYCFLCSCC YHLLLLSLL
//