ID   E5RIG3_HUMAN            Unreviewed;       111 AA.
AC   E5RIG3;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   05-DEC-2018, entry version 49.
DE   SubName: Full=Gamma-aminobutyric acid receptor subunit gamma-2 {ECO:0000313|Ensembl:ENSP00000430732};
GN   Name=GABRG2 {ECO:0000313|Ensembl:ENSP00000430732};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000430732, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000430732, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000430732}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC008611; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC091926; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC091984; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E5RIG3; -.
DR   STRING; 9606.ENSP00000410732; -.
DR   PaxDb; E5RIG3; -.
DR   PeptideAtlas; E5RIG3; -.
DR   PRIDE; E5RIG3; -.
DR   Ensembl; ENST00000522990; ENSP00000430732; ENSG00000113327.
DR   UCSC; uc063jhu.1; human.
DR   EuPathDB; HostDB:ENSG00000113327.14; -.
DR   HGNC; HGNC:4087; GABRG2.
DR   OpenTargets; ENSG00000113327; -.
DR   eggNOG; KOG3642; Eukaryota.
DR   eggNOG; ENOG410XNQG; LUCA.
DR   GeneTree; ENSGT00940000156685; -.
DR   ChiTaRS; GABRG2; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000113327; Expressed in 92 organ(s), highest expression level in middle temporal gyrus.
DR   ExpressionAtlas; E5RIG3; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
DR   GO; GO:0004890; F:GABA-A receptor activity; IEA:InterPro.
DR   GO; GO:0006821; P:chloride transport; IEA:InterPro.
DR   GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:InterPro.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR005439; GABBAg2_rcpt.
DR   InterPro; IPR005437; GABBAg_rcpt.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   PRINTS; PR01620; GABAARGAMMA.
DR   PRINTS; PR01622; GABAARGAMMA2.
DR   SUPFAM; SSF63712; SSF63712; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:E5RIG3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     40       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        41    111       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003198015.
SQ   SEQUENCE   111 AA;  12433 MW;  363BB23F60830340 CRC64;
     MSSPNIWSTG SSVYSTPVFS QKMTVWILLL LSLYPGFTSQ KSDDDYEDYA SNKTWVLTPK
     VPEGDVTVIL NNLLEGYDNK LRPDIGVKPT LIHTDMYVNS IGPVNAINMH H
//