ID E5RIG2_HUMAN Unreviewed; 3565 AA. AC E5RIG2; DT 08-FEB-2011, integrated into UniProtKB/TrEMBL. DT 08-FEB-2011, sequence version 1. DT 16-JAN-2019, entry version 71. DE SubName: Full=CUB and sushi domain-containing protein 1 {ECO:0000313|Ensembl:ENSP00000430733}; GN Name=CSMD1 {ECO:0000313|Ensembl:ENSP00000430733}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000430733, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000430733, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16421571; DOI=10.1038/nature04406; RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., RA Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., RA Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., RA Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T., RA Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., RA DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G., RA Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., RA Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., RA O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K., RA Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., RA Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., RA Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., RA Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., RA Lander E.S.; RT "DNA sequence and analysis of human chromosome 8."; RL Nature 439:331-335(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000430733} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [3] {ECO:0000313|Ensembl:ENSP00000473359} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2013) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC021523; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC023296; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC026991; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC087692; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC135324; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF458665; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF458666; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF458667; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EPD; E5RIG2; -. DR jPOST; E5RIG2; -. DR PRIDE; E5RIG2; -. DR Ensembl; ENST00000520002; ENSP00000430733; ENSG00000183117. DR Ensembl; ENST00000602557; ENSP00000473359; ENSG00000183117. DR UCSC; uc064jzo.1; human. DR EuPathDB; HostDB:ENSG00000183117.18; -. DR HGNC; HGNC:14026; CSMD1. DR OpenTargets; ENSG00000183117; -. DR eggNOG; KOG4297; Eukaryota. DR eggNOG; ENOG410XPJ1; LUCA. DR GeneTree; ENSGT00940000155701; -. DR OMA; ECDWRIK; -. DR ChiTaRS; CSMD1; human. DR Proteomes; UP000005640; Chromosome 8. DR Bgee; ENSG00000183117; Expressed in 135 organ(s), highest expression level in primary visual cortex. DR ExpressionAtlas; E5RIG2; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR CDD; cd00033; CCP; 28. DR CDD; cd00041; CUB; 14. DR Gene3D; 2.60.120.290; -; 14. DR InterPro; IPR000859; CUB_dom. DR InterPro; IPR035914; Sperma_CUB_dom_sf. DR InterPro; IPR035976; Sushi/SCR/CCP_sf. DR InterPro; IPR000436; Sushi_SCR_CCP_dom. DR Pfam; PF00431; CUB; 14. DR Pfam; PF00084; Sushi; 28. DR SMART; SM00032; CCP; 28. DR SMART; SM00042; CUB; 14. DR SUPFAM; SSF49854; SSF49854; 14. DR SUPFAM; SSF57535; SSF57535; 28. DR PROSITE; PS01180; CUB; 14. DR PROSITE; PS50923; SUSHI; 28. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00059, KW ECO:0000256|SAAS:SAAS00887447}; Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|EPD:E5RIG2, KW ECO:0000213|PeptideAtlas:E5RIG2}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 26 {ECO:0000256|SAM:SignalP}. FT CHAIN 27 3565 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014570869. FT TRANSMEM 3489 3510 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 32 140 CUB. {ECO:0000259|PROSITE:PS01180}. FT DOMAIN 143 204 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 208 312 CUB. {ECO:0000259|PROSITE:PS01180}. FT DOMAIN 347 409 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 412 523 CUB. {ECO:0000259|PROSITE:PS01180}. FT DOMAIN 526 583 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 585 693 CUB. {ECO:0000259|PROSITE:PS01180}. FT DOMAIN 696 757 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 759 867 CUB. {ECO:0000259|PROSITE:PS01180}. FT DOMAIN 872 929 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 931 1041 CUB. {ECO:0000259|PROSITE:PS01180}. FT DOMAIN 1044 1103 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 1105 1213 CUB. {ECO:0000259|PROSITE:PS01180}. FT DOMAIN 1216 1276 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 1278 1387 CUB. {ECO:0000259|PROSITE:PS01180}. FT DOMAIN 1390 1450 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 1452 1560 CUB. {ECO:0000259|PROSITE:PS01180}. FT DOMAIN 1563 1624 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 1626 1734 CUB. {ECO:0000259|PROSITE:PS01180}. FT DOMAIN 1740 1801 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 1803 1911 CUB. {ECO:0000259|PROSITE:PS01180}. FT DOMAIN 1914 1973 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 1975 2083 CUB. {ECO:0000259|PROSITE:PS01180}. FT DOMAIN 2086 2145 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 2147 2258 CUB. {ECO:0000259|PROSITE:PS01180}. FT DOMAIN 2257 2318 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 2320 2431 CUB. {ECO:0000259|PROSITE:PS01180}. FT DOMAIN 2431 2493 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 2494 2555 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 2556 2620 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 2621 2678 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 2679 2736 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 2737 2794 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 2795 2857 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 2858 2915 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 2919 2976 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 2977 3035 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 3036 3095 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 3096 3153 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 3154 3211 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 3215 3273 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 3274 3333 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DISULFID 554 581 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 900 927 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 1278 1305 {ECO:0000256|PROSITE-ProRule:PRU00059}. FT DISULFID 2649 2676 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 2707 2734 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 2765 2792 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 2828 2855 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 2886 2913 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 2947 2974 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 3006 3033 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 3124 3151 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 3182 3209 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 3244 3271 {ECO:0000256|PROSITE-ProRule:PRU00302}. SQ SEQUENCE 3565 AA; 388823 MW; 31218D4461751B87 CRC64; MTAWRRFQSL LLLLGLLVLC ARLLTAAKGQ NCGGLVQGPN GTIESPGFPH GYPNYANCTW IIITGERNRI QLSFHTFALE EDFDILSVYD GQPQQGNLKV RLSGFQLPSS IVSTGSILTL WFTTDFAVSA QGFKALYEVL PSHTCGNPGE ILKGVLHGTR FNIGDKIRYS CLPGYILEGH AILTCIVSPG NGASWDFPAP FCRAEGACGG TLRGTSSSIS SPHFPSEYEN NADCTWTILA EPGDTIALVF TDFQLEEGYD FLEISGTEAP SIWLTGMNLP SPVISSKNWL RLHFTSDSNH RRKGFNAQFQ VKKAIELKSR GVKMLPSKDG SHKNSVLSQG GVALVSDMCP DPGIPENGRR AGSDFSRVGA NVQFSCEDNY VLQGSKSITC QRVTETLAAW SDHRPICRAR TCGSNLRGPS GVITSPNYPV QYEDNAHCVW VITTTDPDKV IKLAFEEFEL ERGYDTLTVG DAGKVGDTRS VLYVLTGSSV PDLIVSMSNQ MWLHLQSDDS IGSPGFKAVY QEIEKGGCGD PGIPAYGKRT GSSFLHGDTL TFECPAAFEL VGERVITCQQ NNQWSGNKPS CVFSCFFNFT ASSGIILSPN YPEEYGNNMN CVWLIISEPG SRIHLIFNDF DVEPQFDFLA VKDDGISDIT VLGTFSGNEV PSQLASSGHI VRLEFQSDHS TTGRGFNITY TTFGQNECHD PGIPINGRRF GDRFLLGSSV SFHCDDGFVK TQGSESITCI LQDGNVVWSS TVPRCEAPCG GHLTASSGVI LPPGWPGYYK DSLHCEWIIE AKPGHSIKIT FDRFQTEVNY DTLEVRDGPA SSSPLIGEYH GTQAPQFLIS TGNFMYLLFT TDNSRSSIGF LIHYESVTLE SDSCLDPGIP VNGHRHGGDF GIRSTVTFSC DPGYTLSDDE PLVCERNHQW NHALPSCDAL CGGYIQGKSG TVLSPGFPDF YPNSLNCTWT IEVSHGKGVQ MIFHTFHLES SHDYLLITED GSFSEPVARL TGSVLPHTIK AGLFGNFTAQ LRFISDFSIS YEGFNITFSE YDLEPCDDPG VPAFSRRIGF HFGVGDSLTF SCFLGYRLEG ATKLTCLGGG RRVWSAPLPR CVAECGASVK GNEGTLLSPN FPSNYDNNHE CIYKIETEAG KGIHLRTRSF QLFEGDTLKV YDGKDSSSRP LGTFTKNELL GLILNSTSNH LWLEFNTNGS DTDQGFQLTY TSFDLVKCED PGIPNYGYRI RDEGHFTDTV VLYSCNPGYA MHGSNTLTCL SGDRRVWDKP LPSCIAECGG QIHAATSGRI LSPGYPAPYD NNLHCTWIIE ADPGKTISLH FIVFDTEMAH DILKVWDGPV DSDILLKEWS GSALPEDIHS TFNSLTLQFD SDFFISKSGF SIQFSTSIAA TCNDPGMPQN GTRYGDSREA GDTVTFQCDP GYQLQGQAKI TCVQLNNRFF WQPDPPTCIA ACGGNLTGPA GVILSPNYPQ PYPPGKECDW RVKVNPDFVI ALIFKSFNME PSYDFLHIYE GEDSNSPLIG SYQGSQAPER IESSGNSLFL AFRSDASVGL SGFAIEFKEK PREACFDPGN IMNGTRVGTD FKLGSTITYQ CDSGYKILDP SSITCVIGAD GKPSWDQVLP SCNAPCGGQY TGSEGVVLSP NYPHNYTAGQ ICLYSITVPK EFVVFGQFAY FQTALNDLAE LFDGTHAQAR LLSSLSGSHS GETLPLATSN QILLRFSAKS GASARGFHFV YQAVPRTSDT QCSSVPEPRY GRRIGSEFSA GSIVRFECNP GYLLQGSTAL HCQSVPNALA QWNDTIPSCV VPCSGNFTQR RGTILSPGYP EPYGNNLNCI WKIIVTEGSG IQIQVISFAT EQNWDSLEIH DGGDVTAPRL GSFSGTTVPA LLNSTSNQLY LHFQSDISVA AAGFHLEYKT VGLAACQEPA LPSNSIKIGD RYMVNDVLSF QCEPGYTLQG RSHISCMPGT VRRWNYPSPL CIATCGGTLS TLGGVILSPG FPGSYPNNLD CTWRISLPIG YGAHIQFLNF STEANHDFLE IQNGPYHTSP MIGQFSGTDL PAALLSTTHE TLIHFYSDHS QNRQGFKLAY QAYELQNCPD PPPFQNGYMI NSDYSVGQSV SFECYPGYIL IGHPVLTCQH GINRNWNYPF PRCDAPCGYN VTSQNGTIYS PGFPDEYPIL KDCIWLITVP PGHGVYINFT LLQTEAVNDY IAVWDGPDQN SPQLGVFSGN TALETAYSST NQVLLKFHSD FSNGGFFVLN FHAFQLKKCQ PPPAVPQAEM LTEDDDFEIG DFVKYQCHPG YTLVGTDILT CKLSSQLQFE GSLPTCEAQC PANEVRTGSS GVILSPGYPG NYFNSQTCSW SIKVEPNYNI TIFVDTFQSE KQFDALEVFD GSSGQSPLLV VLSGNHTEQS NFTSRSNQLY LRWSTDHATS KKGFKIRYAA PYCSLTHPLK NGGILNRTAG AVGSKVHYFC KPGYRMVGHS NATCRRNPLG MYQWDSLTPL CQAVSCGIPE SPGNGSFTGN EFTLDSKVVY ECHEGFKLES SQQATAVCQE DGLWSNKGKP PTCKPVACPS IEAQLSEHVI WRLVSGSLNE YGAQVLLSCS PGYYLEGWRL LRCQANGTWN IGDERPSCRV ISCGSLSFPP NGNKIGTLTV YGATAIFTCN TGYTLVGSHV RECLANGLWS GSETRCLAGH CGSPDPIVNG HISGDGFSYR DTVVYQCNPG FRLVGTSVRI CLQDHKWSGQ TPVCVPITCG HPGNPAHGFT NGSEFNLNDV VNFTCNTGYL LQGVSRAQCR SNGQWSSPLP TCRVVNCSDP GFVENAIRHG QQNFPESFEY GMSILYHCKK GFYLLGSSAL TCMANGLWDR SLPKCLAISC GHPGVPANAV LTGELFTYGA VVHYSCRGSE SLIGNDTRVC QEDSHWSGAL PHCTGNNPGF CGDPGTPAHG SRLGDDFKTK SLLRFSCEMG HQLRGSPERT CLLNGSWSGL QPVCEAVSCG NPGTPTNGMI VSSDGILFSS SVIYACWEGY KTSGLMTRHC TANGTWTGTA PDCTIISCGD PGTLANGIQF GTDFTFNKTV SYQCNPGYVM EAVTSATIRC TKDGRWNPSK PVCKAVLCPQ PPPVQNGTVE GSDFRWGSSI SYSCMDGYQL SHSAILSCEG RGVWKGEIPQ CLPVFCGDPG IPAEGRLSGK SFTYKSEVFF QCKSPFILVG SSRRVCQADG TWSGIQPTCI DPAHNTCPDP GTPHFGIQNS SRGYEVGSTV FFRCRKGYHI QGSTTRTCLA NLTWSGIQTE CIPHACRQPE TPAHADVRAI DLPTFGYTLV YTCHPGFFLA GGSEHRTCKA DMKWTGKSPV CKSKGVREVN ETVTKTPVPS DVFFVNSLWK GYYEYLGKRQ PATLTVDWFN ATSSKVNATF SEASPVELKL TGIYKKEEAH LLLKAFQIKG QADIFVSKFE NDNWGLDGYV SSGLERGGFT FQGDIHGKDF GKFKLERQDP LNPDQDSSSH YHGTSSGSVA AAILVPFFAL ILSGFAFYLY KHRTRPKVQY NGYAGHENSN GQASFENPMY DTNLKPTEAK AVRFDTTLNT VCTVV //