ID   E5RIE4_HUMAN            Unreviewed;        93 AA.
AC   E5RIE4;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   16-JAN-2019, entry version 53.
DE   SubName: Full=Integrin beta-2 {ECO:0000313|Ensembl:ENSP00000428434};
GN   Name=ITGB2 {ECO:0000313|Ensembl:ENSP00000428434};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000428434, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000428434, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10830953; DOI=10.1038/35012518;
RG   Chromosome 21 mapping and sequencing consortium;
RA   Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T.,
RA   Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y.,
RA   Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K.,
RA   Polley A., Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D.,
RA   Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W.,
RA   Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S.,
RA   Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E.,
RA   Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P.,
RA   Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H.,
RA   Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E.,
RA   Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F.,
RA   Lehrach H., Reinhardt R., Yaspo M.-L.;
RT   "The DNA sequence of human chromosome 21.";
RL   Nature 405:311-319(2000).
RN   [2] {ECO:0000313|Ensembl:ENSP00000428434}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
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DR   EMBL; AL773603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL844907; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL844908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E5RIE4; -.
DR   jPOST; E5RIE4; -.
DR   MaxQB; E5RIE4; -.
DR   PeptideAtlas; E5RIE4; -.
DR   PRIDE; E5RIE4; -.
DR   Ensembl; ENST00000520389; ENSP00000428434; ENSG00000160255.
DR   UCSC; uc062aui.1; human.
DR   EuPathDB; HostDB:ENSG00000160255.16; -.
DR   HGNC; HGNC:6155; ITGB2.
DR   OpenTargets; ENSG00000160255; -.
DR   eggNOG; KOG1226; Eukaryota.
DR   eggNOG; ENOG410XP60; LUCA.
DR   GeneTree; ENSGT00940000157111; -.
DR   ChiTaRS; ITGB2; human.
DR   Proteomes; UP000005640; Chromosome 21.
DR   Bgee; ENSG00000160255; Expressed in 187 organ(s), highest expression level in blood.
DR   ExpressionAtlas; E5RIE4; baseline and differential.
DR   GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:InterPro.
DR   InterPro; IPR033760; Integrin_beta_N.
DR   InterPro; IPR015812; Integrin_bsu.
DR   InterPro; IPR015439; Integrin_bsu-2.
DR   PANTHER; PTHR10082; PTHR10082; 1.
DR   PANTHER; PTHR10082:SF15; PTHR10082:SF15; 1.
DR   Pfam; PF17205; PSI_integrin; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:E5RIE4,
KW   ECO:0000213|MaxQB:E5RIE4, ECO:0000213|PeptideAtlas:E5RIE4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23     93       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003198590.
FT   DOMAIN       23     49       PSI_integrin. {ECO:0000259|Pfam:PF17205}.
SQ   SEQUENCE   93 AA;  9638 MW;  656E49447AFC2BF0 CRC64;
     MLGLRPPLLA LVGLLSLGCV LSQECTKFKV SSCRECIESG PGCTWCQKLG AALGPPAHAT
     AASSPRRRSR VAPVCPRTEQ GGQAPELHRA GGS
//