ID   E5RIA9_HUMAN            Unreviewed;       213 AA.
AC   E5RIA9;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   16-JAN-2019, entry version 54.
DE   SubName: Full=Mitochondrial peptide methionine sulfoxide reductase {ECO:0000313|Ensembl:ENSP00000429461};
GN   Name=MSRA {ECO:0000313|Ensembl:ENSP00000429461};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000429461, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000429461, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000429461}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC023385; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC034111; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC079200; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC112673; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458680; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E5RIA9; -.
DR   SMR; E5RIA9; -.
DR   jPOST; E5RIA9; -.
DR   MaxQB; E5RIA9; -.
DR   PeptideAtlas; E5RIA9; -.
DR   PRIDE; E5RIA9; -.
DR   Ensembl; ENST00000518255; ENSP00000429461; ENSG00000175806.
DR   UCSC; uc064ked.1; human.
DR   EuPathDB; HostDB:ENSG00000175806.14; -.
DR   HGNC; HGNC:7377; MSRA.
DR   OpenTargets; ENSG00000175806; -.
DR   eggNOG; KOG1635; Eukaryota.
DR   eggNOG; COG0225; LUCA.
DR   GeneTree; ENSGT00390000003823; -.
DR   ChiTaRS; MSRA; human.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000175806; Expressed in 221 organ(s), highest expression level in cortex of kidney.
DR   ExpressionAtlas; E5RIA9; baseline and differential.
DR   GO; GO:0015629; C:actin cytoskeleton; IDA:HPA.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0008113; F:peptide-methionine (S)-S-oxide reductase activity; IEA:InterPro.
DR   Gene3D; 3.30.1060.10; -; 1.
DR   HAMAP; MF_01401; MsrA; 1.
DR   InterPro; IPR002569; Met_Sox_Rdtase_MsrA.
DR   InterPro; IPR036509; Met_Sox_Rdtase_MsrA_sf.
DR   Pfam; PF01625; PMSR; 1.
DR   SUPFAM; SSF55068; SSF55068; 1.
DR   TIGRFAMs; TIGR00401; msrA; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:E5RIA9,
KW   ECO:0000213|MaxQB:E5RIA9, ECO:0000213|PeptideAtlas:E5RIA9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    213       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003198394.
FT   DOMAIN       68    182       PMSR. {ECO:0000259|Pfam:PF01625}.
SQ   SEQUENCE   213 AA;  23596 MW;  B4BEB9E2E4BE6021 CRC64;
     MLSATRRACQ LLLLHSLFPV PRMGNSASNI VSPQEALPGR KEQTPVAAKH HVNGNRTVEP
     FPEGTQMAVF GMGCFWGAER KFWVLKGVYS TQVGFAGGYT SNPTYKEVCS EKTGHAEVVR
     VVYQPEHMSF EELLKVFWEN HDPTQGMRQG NDHGTQYRSA IYPTSAKQME AALSSKENYQ
     KLVLPCSSSA MLGLTAASSA QLAWVQPSSR KHY
//