ID   E5RI87_HUMAN            Unreviewed;       419 AA.
AC   E5RI87;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   16-JAN-2019, entry version 67.
DE   SubName: Full=E3 ubiquitin-protein ligase RNF130 {ECO:0000313|Ensembl:ENSP00000429509};
GN   Name=RNF130 {ECO:0000313|Ensembl:ENSP00000429509};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000429509, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000429509, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000213|PubMed:19690332}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA   Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K.,
RA   Rodionov V., Han D.K.;
RT   "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT   reveals system-wide modulation of protein-protein interactions.";
RL   Sci. Signal. 2:ra46-RA46(2009).
RN   [3] {ECO:0000313|Ensembl:ENSP00000429509}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC010285; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC026413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC122713; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_011532895.1; XM_011534593.2.
DR   UniGene; Hs.484363; -.
DR   ProteinModelPortal; E5RI87; -.
DR   SMR; E5RI87; -.
DR   EPD; E5RI87; -.
DR   jPOST; E5RI87; -.
DR   MaxQB; E5RI87; -.
DR   PRIDE; E5RI87; -.
DR   Ensembl; ENST00000522208; ENSP00000429509; ENSG00000113269.
DR   GeneID; 55819; -.
DR   UCSC; uc063kss.1; human.
DR   CTD; 55819; -.
DR   EuPathDB; HostDB:ENSG00000113269.13; -.
DR   HGNC; HGNC:18280; RNF130.
DR   OpenTargets; ENSG00000113269; -.
DR   eggNOG; KOG0800; Eukaryota.
DR   eggNOG; ENOG41121N2; LUCA.
DR   GeneTree; ENSGT00940000157465; -.
DR   OMA; PLRTSGM; -.
DR   OrthoDB; 1487241at2759; -.
DR   PhylomeDB; E5RI87; -.
DR   ChiTaRS; RNF130; human.
DR   GenomeRNAi; 55819; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000113269; Expressed in 229 organ(s), highest expression level in corpus callosum.
DR   ExpressionAtlas; E5RI87; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR003137; PA_domain.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF02225; PA; 1.
DR   Pfam; PF13639; zf-RING_2; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Proteomics identification {ECO:0000213|MaxQB:E5RI87,
KW   ECO:0000213|PeptideAtlas:E5RI87};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT   SIGNAL        1     27       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        28    419       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003198011.
FT   TRANSMEM    195    218       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      264    305       RING-type. {ECO:0000259|PROSITE:PS50089}.
SQ   SEQUENCE   419 AA;  46504 MW;  C763675F65512102 CRC64;
     MSCAGRAGPA RLAALALLTC SLWPARADNA SQEYYTALIN VTVQEPGRGA PLTFRIDRGR
     YGLDSPKAEV RGQVLAPLPL HGVADHLGCD PQTRFFVPPN IKQWIALLQR GNCTFKEKIS
     RAAFHNAVAV VIYNNKSKEE PVTMTHPGTG DIIAVMITEL RGKDILSYLE KNISVQMTIA
     VGTRMPPKNF SRGSLVFVSI SFIVLMIISS AWLIFYFIQK IRYTNARDRN QRRLGDAAKK
     AISKLTTRTV KKGDKETDPD FDHCAVCIES YKQNDVVRIL PCKHVFHKSC VDPWLSEHCT
     CPMCKLNILK ALGIVPNLPC TDNVAFDMER LTRTQAVNRR SALGDLAGDN SLGLEPLRTS
     GISPLPQDGE LTPRTGEINI AVTSGHFFHR NSLSPRSLVY ESEFSTIEPS LDMYDENKT
//