ID   E5RI22_HUMAN            Unreviewed;       139 AA.
AC   E5RI22;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   16-JAN-2019, entry version 58.
DE   SubName: Full=Lysyl oxidase homolog 2 {ECO:0000313|Ensembl:ENSP00000428497};
DE   Flags: Fragment;
GN   Name=LOXL2 {ECO:0000313|Ensembl:ENSP00000428497};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000428497, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000428497, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000428497}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
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DR   EMBL; AC090197; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC104561; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E5RI22; -.
DR   jPOST; E5RI22; -.
DR   MaxQB; E5RI22; -.
DR   PeptideAtlas; E5RI22; -.
DR   PRIDE; E5RI22; -.
DR   Ensembl; ENST00000524168; ENSP00000428497; ENSG00000134013.
DR   UCSC; uc064lew.1; human.
DR   EuPathDB; HostDB:ENSG00000134013.15; -.
DR   HGNC; HGNC:6666; LOXL2.
DR   OpenTargets; ENSG00000134013; -.
DR   eggNOG; ENOG410IE2X; Eukaryota.
DR   eggNOG; ENOG410XSN1; LUCA.
DR   GeneTree; ENSGT00940000155874; -.
DR   ChiTaRS; LOXL2; human.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000134013; Expressed in 180 organ(s), highest expression level in smooth muscle tissue.
DR   ExpressionAtlas; E5RI22; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR   Gene3D; 3.10.250.10; -; 1.
DR   InterPro; IPR001190; SRCR.
DR   InterPro; IPR017448; SRCR-like_dom.
DR   InterPro; IPR036772; SRCR-like_dom_sf.
DR   Pfam; PF00530; SRCR; 1.
DR   PRINTS; PR00258; SPERACTRCPTR.
DR   SMART; SM00202; SR; 1.
DR   SUPFAM; SSF56487; SSF56487; 1.
DR   PROSITE; PS50287; SRCR_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00196,
KW   ECO:0000256|SAAS:SAAS00873970};
KW   Proteomics identification {ECO:0000213|MaxQB:E5RI22,
KW   ECO:0000213|PeptideAtlas:E5RI22};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    139       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003196872.
FT   DOMAIN       58    139       SRCR. {ECO:0000259|PROSITE:PS50287}.
FT   DISULFID    128    138       {ECO:0000256|PROSITE-ProRule:PRU00196}.
FT   NON_TER     139    139       {ECO:0000313|Ensembl:ENSP00000428497}.
SQ   SEQUENCE   139 AA;  15483 MW;  8657B95C5DDE5793 CRC64;
     MERPLCSHLC SCLAMLALLS PLSLAQYDSW PHYPEYFQQP APEYHQPQAP ANVAKIQLRL
     AGQKRKHSEG RVEVYYDGQW GTVCDDDFSI HAAHVVCREL GYVEAKSWTA SSSYGKGEGP
     IWLDNLHCTG NEATLAACT
//