ID   E5RHT0_HUMAN            Unreviewed;        49 AA.
AC   E5RHT0;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   16-JAN-2019, entry version 66.
DE   SubName: Full=Integrin beta-2 {ECO:0000313|EMBL:AHZ44414.1, ECO:0000313|Ensembl:ENSP00000429683};
DE   Flags: Fragment;
GN   Name=ITGB2 {ECO:0000313|EMBL:AHZ44414.1,
GN   ECO:0000313|Ensembl:ENSP00000429683};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000429683, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000429683, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10830953; DOI=10.1038/35012518;
RG   Chromosome 21 mapping and sequencing consortium;
RA   Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T.,
RA   Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y.,
RA   Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K.,
RA   Polley A., Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D.,
RA   Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W.,
RA   Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S.,
RA   Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E.,
RA   Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P.,
RA   Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H.,
RA   Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E.,
RA   Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F.,
RA   Lehrach H., Reinhardt R., Yaspo M.-L.;
RT   "The DNA sequence of human chromosome 21.";
RL   Nature 405:311-319(2000).
RN   [2] {ECO:0000313|Ensembl:ENSP00000429683}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
RN   [4] {ECO:0000313|EMBL:AHZ44414.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26639818; DOI=10.1016/j.humimm.2015.11.019;
RA   Yassaee V.R., Hashemi-Gorji F., Boosaliki S., Parvaneh N.;
RT   "Mutation spectra of the ITGB2 gene in Iranian families with leukocyte
RT   adhesion deficiency type 1.";
RL   Hum. Immunol. 77:191-195(2016).
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DR   EMBL; AL773603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL844907; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL844908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KJ528562; AHZ44414.1; -; Genomic_DNA.
DR   EMBL; KJ528563; AHZ44415.1; -; Genomic_DNA.
DR   EMBL; KJ528564; AHZ44416.1; -; Genomic_DNA.
DR   UniGene; Hs.375957; -.
DR   jPOST; E5RHT0; -.
DR   MaxQB; E5RHT0; -.
DR   PRIDE; E5RHT0; -.
DR   Ensembl; ENST00000521995; ENSP00000429683; ENSG00000160255.
DR   UCSC; uc062auo.1; human.
DR   EuPathDB; HostDB:ENSG00000160255.16; -.
DR   HGNC; HGNC:6155; ITGB2.
DR   OpenTargets; ENSG00000160255; -.
DR   eggNOG; KOG1226; Eukaryota.
DR   eggNOG; ENOG410XP60; LUCA.
DR   GeneTree; ENSGT00940000157111; -.
DR   ChiTaRS; ITGB2; human.
DR   Proteomes; UP000005640; Chromosome 21.
DR   Bgee; ENSG00000160255; Expressed in 187 organ(s), highest expression level in blood.
DR   ExpressionAtlas; E5RHT0; baseline and differential.
DR   GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR033760; Integrin_beta_N.
DR   InterPro; IPR015812; Integrin_bsu.
DR   InterPro; IPR015439; Integrin_bsu-2.
DR   PANTHER; PTHR10082; PTHR10082; 1.
DR   PANTHER; PTHR10082:SF15; PTHR10082:SF15; 1.
DR   Pfam; PF17205; PSI_integrin; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Integrin {ECO:0000313|EMBL:AHZ44414.1};
KW   Proteomics identification {ECO:0000213|EPD:E5RHT0,
KW   ECO:0000213|MaxQB:E5RHT0, ECO:0000213|PeptideAtlas:E5RHT0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23     49       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014570865.
FT   DOMAIN       23     48       PSI_integrin. {ECO:0000259|Pfam:PF17205}.
FT   NON_TER      49     49       {ECO:0000313|EMBL:AHZ44414.1,
FT                                ECO:0000313|Ensembl:ENSP00000429683}.
SQ   SEQUENCE   49 AA;  5269 MW;  C75444E38FDBB067 CRC64;
     MLGLRPPLLA LVGLLSLGCV LSQECTKFKV SSCRECIESG PGCTWCQKL
//