ID   E5RHN7_HUMAN            Unreviewed;       105 AA.
AC   E5RHN7;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   05-DEC-2018, entry version 58.
DE   SubName: Full=Lipoprotein lipase {ECO:0000313|Ensembl:ENSP00000428557};
DE   Flags: Fragment;
GN   Name=LPL {ECO:0000313|Ensembl:ENSP00000428557};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000428557, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000428557, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000428557}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00553472}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase
CC       family. {ECO:0000256|RuleBase:RU004262,
CC       ECO:0000256|SAAS:SAAS00591292}.
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DR   EMBL; AC100802; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC107964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E5RHN7; -.
DR   PeptideAtlas; E5RHN7; -.
DR   PRIDE; E5RHN7; -.
DR   Ensembl; ENST00000522701; ENSP00000428557; ENSG00000175445.
DR   UCSC; uc064kto.1; human.
DR   EuPathDB; HostDB:ENSG00000175445.14; -.
DR   HGNC; HGNC:6677; LPL.
DR   OpenTargets; ENSG00000175445; -.
DR   eggNOG; ENOG410IJUA; Eukaryota.
DR   eggNOG; ENOG4111GMM; LUCA.
DR   GeneTree; ENSGT00940000157178; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000175445; Expressed in 223 organ(s), highest expression level in adipose tissue.
DR   ExpressionAtlas; E5RHN7; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004465; F:lipoprotein lipase activity; IEA:InterPro.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013818; Lipase/vitellogenin.
DR   InterPro; IPR002330; Lipo_Lipase.
DR   InterPro; IPR000734; TAG_lipase.
DR   PANTHER; PTHR11610; PTHR11610; 1.
DR   PANTHER; PTHR11610:SF3; PTHR11610:SF3; 1.
DR   Pfam; PF00151; Lipase; 1.
DR   PRINTS; PR00822; LIPOLIPASE.
DR   PRINTS; PR00821; TAGLIPASE.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:E5RHN7,
KW   ECO:0000213|PeptideAtlas:E5RHN7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|SAAS:SAAS00439306};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    105       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008413787.
FT   DOMAIN       30    103       Lipase. {ECO:0000259|Pfam:PF00151}.
FT   NON_TER     105    105       {ECO:0000313|Ensembl:ENSP00000428557}.
SQ   SEQUENCE   105 AA;  11636 MW;  D1827FDCF825EC35 CRC64;
     MESKALLVLT LAVWLQSLTA SRGGVAAADQ RRDFIDIESK FALRTPEDTA EDTCHLIPGV
     AESVATCHFN HSSKTFMVIH GWTVTGMYES WVPKLVAALY KREPD
//