ID   E5RHN3_HUMAN            Unreviewed;       273 AA.
AC   E5RHN3;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   16-JAN-2019, entry version 46.
DE   SubName: Full=Hepatitis A virus cellular receptor 2 {ECO:0000313|Ensembl:ENSP00000430873};
GN   Name=HAVCR2 {ECO:0000313|Ensembl:ENSP00000430873};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000430873, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000430873, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000430873}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC010609; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC011377; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E5RHN3; -.
DR   jPOST; E5RHN3; -.
DR   PRIDE; E5RHN3; -.
DR   Ensembl; ENST00000522593; ENSP00000430873; ENSG00000135077.
DR   UCSC; uc063jbu.1; human.
DR   EuPathDB; HostDB:ENSG00000135077.8; -.
DR   HGNC; HGNC:18437; HAVCR2.
DR   OpenTargets; ENSG00000135077; -.
DR   GeneTree; ENSGT00940000154444; -.
DR   ChiTaRS; HAVCR2; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000135077; Expressed in 157 organ(s), highest expression level in layer of synovial tissue.
DR   ExpressionAtlas; E5RHN3; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:E5RHN3,
KW   ECO:0000213|PeptideAtlas:E5RHN3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    273       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003196868.
FT   TRANSMEM    173    196       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        6    124       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   273 AA;  30331 MW;  34B86D233996A8C3 CRC64;
     MFSHLPFDCV LLLLLLLLTR SSEVEYRAEV GQNAYLPCFY TPAAPGNLVP VCWGKGACPV
     FECGNVVLRT DERDVNYWTS RYWLNGDFRK GDVSLTIENV TLADSGIYCC RIQIPGIMND
     EKFNLKLVIK PAETQTLGSL PDINLTQIST LANELRDSRL ANDLRDSGAT IRIGIYIGAG
     ICAGLALALI FGALIFKWYS HSKEKIQNLS LISLANLPPS GLANAVAEGI RSEENIYTIE
     ENVYEVEEPN EYYCYVSSRQ QPSQPLGCRF AMP
//