ID   E5RHL6_HUMAN            Unreviewed;        85 AA.
AC   E5RHL6;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 2.
DT   05-DEC-2018, entry version 46.
DE   SubName: Full=Gamma-aminobutyric acid receptor subunit alpha-1 {ECO:0000313|Ensembl:ENSP00000430895};
DE   Flags: Fragment;
GN   Name=GABRA1 {ECO:0000313|Ensembl:ENSP00000430895};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000430895, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000430895, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000430895}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC021079; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC108130; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PeptideAtlas; E5RHL6; -.
DR   PRIDE; E5RHL6; -.
DR   Ensembl; ENST00000521339; ENSP00000430895; ENSG00000022355.
DR   UCSC; uc063jhp.1; human.
DR   EuPathDB; HostDB:ENSG00000022355.15; -.
DR   HGNC; HGNC:4075; GABRA1.
DR   OpenTargets; ENSG00000022355; -.
DR   eggNOG; KOG3642; Eukaryota.
DR   eggNOG; ENOG410XNQG; LUCA.
DR   GeneTree; ENSGT00940000159136; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000022355; Expressed in 84 organ(s), highest expression level in dorsolateral prefrontal cortex.
DR   ExpressionAtlas; E5RHL6; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
DR   GO; GO:0004890; F:GABA-A receptor activity; IEA:InterPro.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR001390; GABAAa_rcpt.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   PRINTS; PR01079; GABAARALPHA.
DR   SUPFAM; SSF63712; SSF63712; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     27       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        28     85       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008413780.
FT   NON_TER      85     85       {ECO:0000313|Ensembl:ENSP00000430895}.
SQ   SEQUENCE   85 AA;  9630 MW;  0DEEA8861C03D5E6 CRC64;
     MRKSPGLSDC LWAWILLLST LTGRSYGQPS LQDELKDNTT VFTRILDRLL DGYDNRLRPG
     LGERVTEVKT DIFVTSFGPV SDHDM
//