ID   E5RHG4_HUMAN            Unreviewed;       157 AA.
AC   E5RHG4;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   16-JAN-2019, entry version 64.
DE   SubName: Full=Tissue-type plasminogen activator {ECO:0000313|Ensembl:ENSP00000429801};
DE   Flags: Fragment;
GN   Name=PLAT {ECO:0000313|Ensembl:ENSP00000429801};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000429801, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000429801, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000429801}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC083973; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC103724; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   jPOST; E5RHG4; -.
DR   MaxQB; E5RHG4; -.
DR   PeptideAtlas; E5RHG4; -.
DR   PRIDE; E5RHG4; -.
DR   Ensembl; ENST00000521694; ENSP00000429801; ENSG00000104368.
DR   UCSC; uc064mjx.1; human.
DR   EuPathDB; HostDB:ENSG00000104368.17; -.
DR   HGNC; HGNC:9051; PLAT.
DR   OpenTargets; ENSG00000104368; -.
DR   eggNOG; KOG3627; Eukaryota.
DR   eggNOG; COG5640; LUCA.
DR   GeneTree; ENSGT00940000158930; -.
DR   ChiTaRS; PLAT; human.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000104368; Expressed in 217 organ(s), highest expression level in metanephric glomerulus.
DR   ExpressionAtlas; E5RHG4; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0031639; P:plasminogen activation; IEA:InterPro.
DR   CDD; cd00061; FN1; 1.
DR   Gene3D; 2.40.20.10; -; 1.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000083; Fibronectin_type1.
DR   InterPro; IPR000001; Kringle.
DR   InterPro; IPR013806; Kringle-like.
DR   InterPro; IPR038178; Kringle_sf.
DR   InterPro; IPR034811; tPA.
DR   PANTHER; PTHR44617; PTHR44617; 1.
DR   Pfam; PF00008; EGF; 1.
DR   Pfam; PF00039; fn1; 1.
DR   Pfam; PF00051; Kringle; 1.
DR   SMART; SM00058; FN1; 1.
DR   SUPFAM; SSF57440; SSF57440; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 1.
DR   PROSITE; PS01253; FN1_1; 1.
DR   PROSITE; PS51091; FN1_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Proteomics identification {ECO:0000213|MaxQB:E5RHG4,
KW   ECO:0000213|PeptideAtlas:E5RHG4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    157       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003196818.
FT   DOMAIN       39     81       Fibronectin type-I.
FT                                {ECO:0000259|PROSITE:PS51091}.
FT   DOMAIN       82    120       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DISULFID     91    108       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    110    119       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   NON_TER     157    157       {ECO:0000313|Ensembl:ENSP00000429801}.
SQ   SEQUENCE   157 AA;  17684 MW;  97925D641E0AE3A7 CRC64;
     MDAMKRGLCC VLLLCGAVFV SPSQEIHARF RRGARSYQVI CRDEKTQMIY QQHQSWLRPV
     LRSNRVEYCW CNSGRAQCHS VPVKSCSEPR CFNGGTCQQA LYFSDFVCQC PEGFAGKCCE
     IDTRATCYED QGISYRGTWS TAESGAECTN WNSSALA
//