ID   E5RHD4_HUMAN            Unreviewed;       173 AA.
AC   E5RHD4;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   05-DEC-2018, entry version 47.
DE   SubName: Full=Transcription factor E2F5 {ECO:0000313|Ensembl:ENSP00000428606};
GN   Name=E2F5 {ECO:0000313|Ensembl:ENSP00000428606};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000428606, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000428606, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000428606}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC011773; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF573693; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E5RHD4; -.
DR   MaxQB; E5RHD4; -.
DR   PeptideAtlas; E5RHD4; -.
DR   PRIDE; E5RHD4; -.
DR   Ensembl; ENST00000521429; ENSP00000428606; ENSG00000133740.
DR   UCSC; uc064oce.1; human.
DR   EuPathDB; HostDB:ENSG00000133740.10; -.
DR   HGNC; HGNC:3119; E2F5.
DR   OpenTargets; ENSG00000133740; -.
DR   eggNOG; KOG2577; Eukaryota.
DR   eggNOG; ENOG410XNYI; LUCA.
DR   GeneTree; ENSGT00940000157353; -.
DR   ChiTaRS; E2F5; human.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000133740; Expressed in 152 organ(s), highest expression level in kidney.
DR   ExpressionAtlas; E5RHD4; baseline and differential.
DR   GO; GO:0001650; C:fibrillar center; IDA:HPA.
DR   GO; GO:0005730; C:nucleolus; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; IDA:HPA.
DR   GO; GO:0005667; C:transcription factor complex; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR   InterPro; IPR015633; E2F.
DR   InterPro; IPR037241; E2F-DP_heterodim.
DR   InterPro; IPR028316; E2F5.
DR   InterPro; IPR032198; E2F_CC-MB.
DR   PANTHER; PTHR12081; PTHR12081; 2.
DR   PANTHER; PTHR12081:SF35; PTHR12081:SF35; 2.
DR   Pfam; PF16421; E2F_CC-MB; 1.
DR   SUPFAM; SSF144074; SSF144074; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:E5RHD4,
KW   ECO:0000213|PeptideAtlas:E5RHD4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     16       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        17    173       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003196866.
FT   DOMAIN       10     57       E2F_CC-MB. {ECO:0000259|Pfam:PF16421}.
SQ   SEQUENCE   173 AA;  18677 MW;  217ADCDAA57B67FB CRC64;
     MKTSVIALMV SDTLLAIQAP SGTQLEVPIP EMGQNGQKKY QINLKSHSGP IHVLLINKES
     SSSKPVVFPV PPPDDLTQPS SQSLTPVTPQ KSSMATQNLP EQHVSERSQA LQQTSATDIS
     SAGSISGDII DELMSSDVFP LLRLSPTPAD DYNFNLDDNE GVCDLFDVQI LNY
//