ID   E5RH25_HUMAN            Unreviewed;       121 AA.
AC   E5RH25;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   05-DEC-2018, entry version 46.
DE   SubName: Full=R-spondin-2 {ECO:0000313|Ensembl:ENSP00000430010};
DE   Flags: Fragment;
GN   Name=RSPO2 {ECO:0000313|Ensembl:ENSP00000430010};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000430010, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000430010, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000430010}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC025508; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP003479; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877305; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E5RH25; -.
DR   PRIDE; E5RH25; -.
DR   Ensembl; ENST00000521956; ENSP00000430010; ENSG00000147655.
DR   UCSC; uc064pmg.1; human.
DR   EuPathDB; HostDB:ENSG00000147655.10; -.
DR   HGNC; HGNC:28583; RSPO2.
DR   OpenTargets; ENSG00000147655; -.
DR   eggNOG; ENOG410IMS2; Eukaryota.
DR   eggNOG; ENOG410ZI6H; LUCA.
DR   GeneTree; ENSGT00940000159194; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000147655; Expressed in 100 organ(s), highest expression level in lung.
DR   ExpressionAtlas; E5RH25; baseline and differential.
DR   InterPro; IPR006212; Furin_repeat.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   Pfam; PF15913; Furin-like_2; 1.
DR   SUPFAM; SSF57184; SSF57184; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    121       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003198561.
FT   NON_TER     121    121       {ECO:0000313|Ensembl:ENSP00000430010}.
SQ   SEQUENCE   121 AA;  14235 MW;  2986253E2E32FA84 CRC64;
     MQFRLFSFAL IILNCMDYSH CQGNRWRRSK RASYVSNPIC KGCLSCSKDN GCSRCQQKLF
     FFLRREGMRQ YGECLHSCPS GYYGHRAPDM NRCARCRIEN CDSCFSKDFC TKCKVGFYLH
     R
//