ID   E5RGS2_HUMAN            Unreviewed;       251 AA.
AC   E5RGS2;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   16-JAN-2019, entry version 64.
DE   RecName: Full=Receptor expression-enhancing protein {ECO:0000256|RuleBase:RU362006};
GN   Name=REEP4 {ECO:0000313|Ensembl:ENSP00000428709};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000428709, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000213|PubMed:17081983}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA   Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,
RA   Mann M.;
RT   "Global, in vivo, and site-specific phosphorylation dynamics in
RT   signaling networks.";
RL   Cell 127:635-648(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000428709, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [3] {ECO:0000213|PubMed:18669648}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [4] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [5] {ECO:0000213|PubMed:21406692}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA   Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
RA   Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
RA   Blagoev B.;
RT   "System-wide temporal characterization of the proteome and
RT   phosphoproteome of human embryonic stem cell differentiation.";
RL   Sci. Signal. 4:rs3-RS3(2011).
RN   [6] {ECO:0000313|Ensembl:ENSP00000428709}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [7] {ECO:0000213|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [8] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362006};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU362006}.
CC   -!- SIMILARITY: Belongs to the DP1 family.
CC       {ECO:0000256|RuleBase:RU362006}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU362006}.
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DR   EMBL; AC105206; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001303893.1; NM_001316964.1.
DR   UniGene; Hs.289063; -.
DR   ProteinModelPortal; E5RGS2; -.
DR   SMR; E5RGS2; -.
DR   SwissPalm; E5RGS2; -.
DR   EPD; E5RGS2; -.
DR   jPOST; E5RGS2; -.
DR   MaxQB; E5RGS2; -.
DR   PeptideAtlas; E5RGS2; -.
DR   PRIDE; E5RGS2; -.
DR   Ensembl; ENST00000523293; ENSP00000428709; ENSG00000168476.
DR   GeneID; 80346; -.
DR   UCSC; uc064kxr.1; human.
DR   CTD; 80346; -.
DR   EuPathDB; HostDB:ENSG00000168476.11; -.
DR   HGNC; HGNC:26176; REEP4.
DR   OpenTargets; ENSG00000168476; -.
DR   eggNOG; KOG1726; Eukaryota.
DR   eggNOG; COG5052; LUCA.
DR   GeneTree; ENSGT00940000161674; -.
DR   OMA; APTYQDP; -.
DR   OrthoDB; 1473891at2759; -.
DR   ChiTaRS; REEP4; human.
DR   GenomeRNAi; 80346; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000168476; Expressed in 169 organ(s), highest expression level in skin of abdomen.
DR   ExpressionAtlas; E5RGS2; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR004345; TB2_DP1_HVA22.
DR   PANTHER; PTHR12300; PTHR12300; 1.
DR   Pfam; PF03134; TB2_DP1_HVA22; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|RuleBase:RU362006};
KW   Proteomics identification {ECO:0000213|EPD:E5RGS2,
KW   ECO:0000213|MaxQB:E5RGS2, ECO:0000213|PeptideAtlas:E5RGS2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|RuleBase:RU362006};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU362006}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    251       Receptor expression-enhancing protein.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003198348.
FT   TRANSMEM     38     62       Helical. {ECO:0000256|RuleBase:RU362006}.
SQ   SEQUENCE   251 AA;  28214 MW;  92A5BAA140E9B67B CRC64;
     MVSWMICRLV VLVFGMLCPA YASYKAVKTK NIREYVRWMM YWIVFALFMA AEIVTDIFIS
     WFPFYYEIKM AFVLWLLSPY TKGASLLYRK FVHPSLSRHE KEIDAYIVQA KERSYETVLS
     FGKRGLNIAA SAAVQAATKS QGALAGRLRS FSMQDLRSIS DAPAPAYHDP LYLEDQVSHR
     RPPIGHLALP EGSDEEKDCA LRRGQLGSAA SAPFLPRALQ GSRAIWRDLG LHIWPACTSC
     LGPTLLTPAD G
//