ID   E5RGR6_HUMAN            Unreviewed;       264 AA.
AC   E5RGR6;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 6.
DT   05-DEC-2018, entry version 52.
DE   SubName: Full=GDNF family receptor alpha-2 {ECO:0000313|Ensembl:ENSP00000428721};
DE   Flags: Fragment;
GN   Name=GFRA2 {ECO:0000313|Ensembl:ENSP00000428721};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000428721, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000428721, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000428721}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC105186; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC129925; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP008236; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877225; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E5RGR6; -.
DR   PeptideAtlas; E5RGR6; -.
DR   PRIDE; E5RGR6; -.
DR   Ensembl; ENST00000522071; ENSP00000428721; ENSG00000168546.
DR   UCSC; uc064kva.1; human.
DR   EuPathDB; HostDB:ENSG00000168546.10; -.
DR   HGNC; HGNC:4244; GFRA2.
DR   OpenTargets; ENSG00000168546; -.
DR   eggNOG; ENOG410IU4F; Eukaryota.
DR   eggNOG; ENOG410XPTA; LUCA.
DR   GeneTree; ENSGT00940000156168; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000168546; Expressed in 145 organ(s), highest expression level in anterior cingulate cortex.
DR   ExpressionAtlas; E5RGR6; baseline and differential.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   InterPro; IPR016017; GDNF/GAS1.
DR   InterPro; IPR003438; GDNF_rcpt.
DR   InterPro; IPR003504; GDNF_rcpt_a2.
DR   PANTHER; PTHR10269; PTHR10269; 1.
DR   Pfam; PF02351; GDNF; 2.
DR   PRINTS; PR01318; GDNFRALPHA2.
DR   PRINTS; PR01316; GDNFRECEPTOR.
DR   SMART; SM00907; GDNF; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:E5RGR6,
KW   ECO:0000213|PeptideAtlas:E5RGR6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    264       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008413777.
FT   DOMAIN       40    117       GDNF. {ECO:0000259|SMART:SM00907}.
FT   DOMAIN      161    241       GDNF. {ECO:0000259|SMART:SM00907}.
FT   NON_TER     264    264       {ECO:0000313|Ensembl:ENSP00000428721}.
SQ   SEQUENCE   264 AA;  30176 MW;  48C9E7310C254582 CRC64;
     MILANVFCLF FFLDETLRSL ASPSSLQGPE LHGWRPPVDC VRANELCAAE SNCSSRYRTL
     RQCLAGRDRN TMLANKECQA ALEVLQESPL YDCRCKRGMK KELQCLQIYW SIHLGLTEGE
     EFYEASPYEP VTSRLSDIFR LASIFSGTGA DPVVSAKSNH CLDAAKACNL NDNCKKLRSS
     YISICNREIS PTERCNRRKC HKALRQFFDR VPSEYTYRML FCSCQDQACA ERRRQTILPS
     CSYEDKEKPN CLDLRGVCRT DHLC
//