ID   E5RGB0_HUMAN            Unreviewed;       129 AA.
AC   E5RGB0;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   16-JAN-2019, entry version 50.
DE   SubName: Full=Clusterin {ECO:0000313|Ensembl:ENSP00000428779};
DE   Flags: Fragment;
GN   Name=CLU {ECO:0000313|Ensembl:ENSP00000428779};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000428779, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000428779, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000428779}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AF311103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E5RGB0; -.
DR   jPOST; E5RGB0; -.
DR   MaxQB; E5RGB0; -.
DR   PeptideAtlas; E5RGB0; -.
DR   PRIDE; E5RGB0; -.
DR   Ensembl; ENST00000522413; ENSP00000428779; ENSG00000120885.
DR   UCSC; uc064lma.1; human.
DR   EuPathDB; HostDB:ENSG00000120885.19; -.
DR   HGNC; HGNC:2095; CLU.
DR   OpenTargets; ENSG00000120885; -.
DR   eggNOG; ENOG410IHRB; Eukaryota.
DR   eggNOG; ENOG410YYKB; LUCA.
DR   GeneTree; ENSGT00530000063668; -.
DR   ChiTaRS; CLU; human.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000120885; Expressed in 238 organ(s), highest expression level in tendon of biceps brachii.
DR   ExpressionAtlas; E5RGB0; baseline and differential.
DR   InterPro; IPR016016; Clusterin.
DR   InterPro; IPR000753; Clusterin-like.
DR   InterPro; IPR033986; Clusterin_CS.
DR   InterPro; IPR016014; Clusterin_N.
DR   PANTHER; PTHR10970; PTHR10970; 1.
DR   PANTHER; PTHR10970:SF1; PTHR10970:SF1; 1.
DR   Pfam; PF01093; Clusterin; 1.
DR   SMART; SM00030; CLb; 1.
DR   PROSITE; PS00492; CLUSTERIN_1; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:E5RGB0,
KW   ECO:0000213|MaxQB:E5RGB0, ECO:0000213|PeptideAtlas:E5RGB0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    129       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003197965.
FT   DOMAIN       23    129       CLb. {ECO:0000259|SMART:SM00030}.
FT   COILED       53     94       {ECO:0000256|SAM:Coils}.
FT   NON_TER     129    129       {ECO:0000313|Ensembl:ENSP00000428779}.
SQ   SEQUENCE   129 AA;  14779 MW;  589F06A3D108F95C CRC64;
     MMKTLLLFVG LLLTWESGQV LGDQTVSDNE LQEMSNQGSK YVNKEIQNAV NGVKQIKTLI
     EKTNEERKTL LSNLEEAKKK KEDALNETRE SETKLKELPG VCNETMMALW EECKPCLKQT
     CMKFYARVC
//