ID   E5RGA1_HUMAN            Unreviewed;       178 AA.
AC   E5RGA1;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   16-JAN-2019, entry version 64.
DE   SubName: Full=Tissue-type plasminogen activator {ECO:0000313|Ensembl:ENSP00000428797};
DE   Flags: Fragment;
GN   Name=PLAT {ECO:0000313|Ensembl:ENSP00000428797};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000428797, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000428797, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000428797}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00121}.
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DR   EMBL; AC083973; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC103724; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E5RGA1; -.
DR   jPOST; E5RGA1; -.
DR   MaxQB; E5RGA1; -.
DR   PeptideAtlas; E5RGA1; -.
DR   PRIDE; E5RGA1; -.
DR   Ensembl; ENST00000520523; ENSP00000428797; ENSG00000104368.
DR   UCSC; uc064mjw.1; human.
DR   EuPathDB; HostDB:ENSG00000104368.17; -.
DR   HGNC; HGNC:9051; PLAT.
DR   OpenTargets; ENSG00000104368; -.
DR   eggNOG; KOG3627; Eukaryota.
DR   eggNOG; COG5640; LUCA.
DR   GeneTree; ENSGT00940000158930; -.
DR   ChiTaRS; PLAT; human.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000104368; Expressed in 217 organ(s), highest expression level in metanephric glomerulus.
DR   ExpressionAtlas; E5RGA1; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0031639; P:plasminogen activation; IEA:InterPro.
DR   CDD; cd00061; FN1; 1.
DR   Gene3D; 2.40.20.10; -; 1.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000083; Fibronectin_type1.
DR   InterPro; IPR000001; Kringle.
DR   InterPro; IPR013806; Kringle-like.
DR   InterPro; IPR038178; Kringle_sf.
DR   InterPro; IPR034811; tPA.
DR   PANTHER; PTHR44617; PTHR44617; 1.
DR   Pfam; PF00008; EGF; 1.
DR   Pfam; PF00039; fn1; 1.
DR   Pfam; PF00051; Kringle; 1.
DR   SMART; SM00058; FN1; 1.
DR   SMART; SM00130; KR; 1.
DR   SUPFAM; SSF57440; SSF57440; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 1.
DR   PROSITE; PS01253; FN1_1; 1.
DR   PROSITE; PS51091; FN1_2; 1.
DR   PROSITE; PS50070; KRINGLE_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00045912};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Kringle {ECO:0000256|PROSITE-ProRule:PRU00121,
KW   ECO:0000256|SAAS:SAAS00045973};
KW   Proteomics identification {ECO:0000213|MaxQB:E5RGA1,
KW   ECO:0000213|PeptideAtlas:E5RGA1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    178       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003198541.
FT   DOMAIN       39     81       Fibronectin type-I.
FT                                {ECO:0000259|PROSITE:PS51091}.
FT   DOMAIN       82    120       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      126    178       Kringle. {ECO:0000259|PROSITE:PS50070}.
FT   DISULFID     91    108       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    110    119       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   NON_TER     178    178       {ECO:0000313|Ensembl:ENSP00000428797}.
SQ   SEQUENCE   178 AA;  20079 MW;  E95ED63B8D766AAB CRC64;
     MDAMKRGLCC VLLLCGAVFV SPSQEIHARF RRGARSYQVI CRDEKTQMIY QQHQSWLRPV
     LRSNRVEYCW CNSGRAQCHS VPVKSCSEPR CFNGGTCQQA LYFSDFVCQC PEGFAGKCCE
     IDTRATCYED QGISYRGTWS TAESGAECTN WNSSALAQKP YSGRRPDAIR LGLGNHNY
//