ID   E5RG74_HUMAN            Unreviewed;      1159 AA.
AC   E5RG74;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   16-JAN-2019, entry version 62.
DE   SubName: Full=Adhesion G protein-coupled receptor B1 {ECO:0000313|Ensembl:ENSP00000427783};
GN   Name=ADGRB1 {ECO:0000313|Ensembl:ENSP00000427783};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000427783, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000427783, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000427783}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC       {ECO:0000256|SAAS:SAAS00978931}.
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DR   EMBL; AC134682; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC139676; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E5RG74; -.
DR   SMR; E5RG74; -.
DR   jPOST; E5RG74; -.
DR   PeptideAtlas; E5RG74; -.
DR   PRIDE; E5RG74; -.
DR   Ensembl; ENST00000521208; ENSP00000427783; ENSG00000181790.
DR   UCSC; uc064quo.1; human.
DR   EuPathDB; HostDB:ENSG00000181790.10; -.
DR   HGNC; HGNC:943; ADGRB1.
DR   OpenTargets; ENSG00000181790; -.
DR   eggNOG; ENOG410IEA0; Eukaryota.
DR   eggNOG; ENOG4111FBM; LUCA.
DR   GeneTree; ENSGT00940000157432; -.
DR   ChiTaRS; ADGRB1; human.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000181790; Expressed in 129 organ(s), highest expression level in anterior cingulate cortex.
DR   ExpressionAtlas; E5RG74; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR   Gene3D; 2.20.100.10; -; 5.
DR   Gene3D; 4.10.1240.10; -; 1.
DR   InterPro; IPR032471; GAIN_dom_N.
DR   InterPro; IPR017981; GPCR_2-like.
DR   InterPro; IPR008077; GPCR_2_brain_angio_inhib.
DR   InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR   InterPro; IPR001879; GPCR_2_extracellular_dom.
DR   InterPro; IPR000832; GPCR_2_secretin-like.
DR   InterPro; IPR000203; GPS.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   Pfam; PF00002; 7tm_2; 1.
DR   Pfam; PF16489; GAIN; 1.
DR   Pfam; PF01825; GPS; 1.
DR   Pfam; PF02793; HRM; 1.
DR   Pfam; PF00090; TSP_1; 5.
DR   PRINTS; PR01694; BAIPRECURSOR.
DR   SMART; SM00303; GPS; 1.
DR   SMART; SM00008; HormR; 1.
DR   SMART; SM00209; TSP1; 5.
DR   SUPFAM; SSF82895; SSF82895; 5.
DR   PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR   PROSITE; PS50221; GPS; 1.
DR   PROSITE; PS50092; TSP1; 5.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   G-protein coupled receptor {ECO:0000256|SAAS:SAAS00978998};
KW   Membrane {ECO:0000256|SAAS:SAAS00520444, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:E5RG74};
KW   Receptor {ECO:0000256|SAAS:SAAS00978998};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transducer {ECO:0000256|SAAS:SAAS00978998};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00520444,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00520444,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     30       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        31   1159       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003198537.
FT   TRANSMEM    949    970       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    982   1001       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1013   1031       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1052   1071       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1091   1111       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      568    638       G_PROTEIN_RECEP_F2_3.
FT                                {ECO:0000259|PROSITE:PS50227}.
FT   DOMAIN      881    938       GPS. {ECO:0000259|PROSITE:PS50221}.
FT   DOMAIN      947   1104       G_PROTEIN_RECEP_F2_4.
FT                                {ECO:0000259|PROSITE:PS50261}.
SQ   SEQUENCE   1159 AA;  126688 MW;  47194EEFA3CC8880 CRC64;
     MRGQAAAPGP VWILAPLLLL LLLLGRRARA AAGADAGPGP EPCATLVQGK FFGYFSAAAV
     FPANASRCSW TLRNPDPRRY TLYMKVAKAP VPCSGPGRVR TYQFDSFLES TRTYLGVESF
     DEVLRLCDPS APLAFLQASK QFLQMRRQQP PQHDGLRPRA GPPGPTDDFS VEYLVVGNRN
     PSRAACQMLC RWLDACLAGS RSSHPCGIMQ TPCACLGGEA GGPAAGPLAP RGDVCLRDAV
     AGGPENCLTS LTQDRGGHGA TGGWKLWSLW GECTRDCGGG LQTRTRTCLP APGVEGGGCE
     GVLEEGRQCN REACGPAGRT SSRSQSLRST DARRREELGD ELQQFGFPAP QTGDPAAEEW
     SPWSVCSSTC GEGWQTRTRF CVSSSYSTQC SGPLREQRLC NNSAVCPVHG AWDEWSPWSL
     CSSTCGRGFR DRTRTCRPPQ FGGNPCEGPE KQTKFCNIAL CPGRAVDGNW NEWSSWSACS
     ASCSQGRQQR TRECNGPSYG GAECQGHWVE TRDCFLQQCP VDGKWQAWAS WGSCSVTCGA
     GSQRRERVCS GPFFGGAACQ GPQDEYRQCG TQRCPEPHEI CDEDNFGAVI WKETPAGEVA
     AVRCPRNATG LILRRCELDE EGIAYWEPPT YIRCVSIDYR NIQMMTREHL AKAQRGLPGE
     GVSEVIQTLV EISQDGTSYS GDLLSTIDVL RNMTEIFRRA YYSPTPGDVQ NFVQILSNLL
     AEENRDKWEE AQLAGPNAKE LFRLVEDFVD VIGFRMKDLR DAYQVTDNLV LSIHKLPASG
     ATDISFPMKG WRATGDWAKV PEDRVTVSKS VFSTGLTEAD EASVFVVGTV LYRNLGSFLA
     LQRNTTVLNS KVISVTVKPP PRSLRTPLEI EFAHMYNGTT NQTCILWDET DVPSSSAPPQ
     LGPWSWRGCR TVPLDALRTR CLCDRLSTFA ILAQLSADAN MEKATLPSVT LIVGCGVSSL
     TLLMLVIIYV SVWRYIRSER SVILINFCLS IISSNALILI GQTQTRNKVV CTLVAAFLHF
     FFLSSFCWVL TEAWQSYMAV TGHLRNRLIR KRFLCLGWGL PALVVAISVG FTKAKGYSTM
     NYCWLSLEGG LLYAFVGPAA AVVLGLPVEL LRGAAAAGAD LDVGCARRHR PPLRPLPDPL
     RCLRLAGGLR HRHGALYPP
//