ID   E5RG32_HUMAN            Unreviewed;       138 AA.
AC   E5RG32;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   16-JAN-2019, entry version 56.
DE   RecName: Full=Glutathione peroxidase {ECO:0000256|RuleBase:RU000499};
DE   Flags: Fragment;
GN   Name=GPX3 {ECO:0000313|Ensembl:ENSP00000427873};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000427873, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000427873, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000427873}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the glutathione peroxidase family.
CC       {ECO:0000256|RuleBase:RU000499}.
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DR   EMBL; AC008641; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   jPOST; E5RG32; -.
DR   PeptideAtlas; E5RG32; -.
DR   PRIDE; E5RG32; -.
DR   Ensembl; ENST00000521650; ENSP00000427873; ENSG00000211445.
DR   UCSC; uc063itj.1; human.
DR   EuPathDB; HostDB:ENSG00000211445.11; -.
DR   HGNC; HGNC:4555; GPX3.
DR   OpenTargets; ENSG00000211445; -.
DR   GeneTree; ENSGT00940000161754; -.
DR   ChiTaRS; GPX3; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000211445; Expressed in 236 organ(s), highest expression level in thyroid gland.
DR   ExpressionAtlas; E5RG32; baseline and differential.
DR   GO; GO:0004602; F:glutathione peroxidase activity; IEA:InterPro.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   InterPro; IPR000889; Glutathione_peroxidase.
DR   InterPro; IPR029759; GPX_AS.
DR   InterPro; IPR029760; GPX_CS.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR11592; PTHR11592; 1.
DR   Pfam; PF00255; GSHPx; 1.
DR   PIRSF; PIRSF000303; Glutathion_perox; 1.
DR   PRINTS; PR01011; GLUTPROXDASE.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS00460; GLUTATHIONE_PEROXID_1; 1.
DR   PROSITE; PS00763; GLUTATHIONE_PEROXID_2; 1.
DR   PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000499};
KW   Peroxidase {ECO:0000256|RuleBase:RU000499};
KW   Proteomics identification {ECO:0000213|MaxQB:E5RG32,
KW   ECO:0000213|PeptideAtlas:E5RG32};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    138       Glutathione peroxidase.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008413775.
FT   ACT_SITE     82     82       {ECO:0000256|PIRSR:PIRSR000303-1}.
FT   NON_TER     138    138       {ECO:0000313|Ensembl:ENSP00000427873}.
SQ   SEQUENCE   138 AA;  15018 MW;  26A2DC9B84FC558B CRC64;
     MARLLQASCL LSLLLAGFVS QSRGQEKSKA PRQMGNPQMD CHGGISGTIY EYGALTIDGE
     EYIPFKQYAG KYVLFVNVAS YCGLTGQYIE LNALQEELAP FGLVILGFPC NQFGKQEPGE
     NSEILPTLKY VRPGGGFV
//