ID   E5RFV7_HUMAN            Unreviewed;       145 AA.
AC   E5RFV7;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   16-JAN-2019, entry version 52.
DE   SubName: Full=Tumor necrosis factor receptor superfamily member 11B {ECO:0000313|Ensembl:ENSP00000427924};
GN   Name=TNFRSF11B {ECO:0000313|Ensembl:ENSP00000427924};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000427924, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000427924, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000427924}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR   EMBL; AC107953; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP004283; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E5RFV7; -.
DR   jPOST; E5RFV7; -.
DR   PeptideAtlas; E5RFV7; -.
DR   PRIDE; E5RFV7; -.
DR   Ensembl; ENST00000517352; ENSP00000427924; ENSG00000164761.
DR   UCSC; uc064ptc.1; human.
DR   EuPathDB; HostDB:ENSG00000164761.8; -.
DR   HGNC; HGNC:11909; TNFRSF11B.
DR   OpenTargets; ENSG00000164761; -.
DR   eggNOG; ENOG410IFEM; Eukaryota.
DR   eggNOG; ENOG4111PUQ; LUCA.
DR   GeneTree; ENSGT00940000155167; -.
DR   ChiTaRS; TNFRSF11B; human.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000164761; Expressed in 159 organ(s), highest expression level in tendon of biceps brachii.
DR   ExpressionAtlas; E5RFV7; baseline and differential.
DR   InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR   InterPro; IPR017371; TNFR_11B.
DR   Pfam; PF00020; TNFR_c6; 2.
DR   PRINTS; PR01975; TNFACTORR11B.
DR   SMART; SM00208; TNFR; 3.
DR   PROSITE; PS50050; TNFR_NGFR_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:E5RFV7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    145       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003196858.
FT   DOMAIN       64    105       TNFR-Cys. {ECO:0000259|PROSITE:PS50050}.
FT   REPEAT       64    105       TNFR-Cys. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00206}.
FT   DISULFID     65     80       {ECO:0000256|PROSITE-ProRule:PRU00206}.
FT   DISULFID     87    105       {ECO:0000256|PROSITE-ProRule:PRU00206}.
SQ   SEQUENCE   145 AA;  16943 MW;  3AD48777C60E1305 CRC64;
     MNNLLCCALV FLDISIKWTT QETFPPKYLH YDEETSHQLL CDKCPPGTYL KQHCTAKWKT
     VCAPCPDHYY TDSWHTSDEC LYCSPVCKEL QYVKQECNRT HNRVCECKEG RYLEIEFCLK
     HRSCPPGFGV VQAGCRRRPK PQICI
//